YOR153W - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOR153W YOR153W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PDR5 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''LEM1, STS1, YDR1''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:619841..624376
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72
{{SGDpaper|S000040660}} PMID 8810273</ref>
 
 
 
 

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==Community Commentary==
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==References==

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@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:619841..624376
+|nowrap| Chr XV:619840..624375
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005679

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR153W:''' Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72 {{SGDpaper|S000040660}} PMID 8810273</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000060194'>Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14 {{SGDpaper|S000060194}} PMID 11321575</ref><ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61
+'''Description of YOR153W:''' Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72 {{SGDpaper|S000040660}} PMID 8810273</ref><ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000060194'>Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14
-  {{SGDpaper|S000069994}} PMID 12067726</ref>
+  {{SGDpaper|S000060194}} PMID 11321575</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR153W:''' Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000060194'>Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14 {{SGDpaper|S000060194}} PMID 11321575</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72
+'''Description of YOR153W:''' Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72 {{SGDpaper|S000040660}} PMID 8810273</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000060194'>Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14 {{SGDpaper|S000060194}} PMID 11321575</ref><ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61
-  {{SGDpaper|S000040660}} PMID 8810273</ref>
+  {{SGDpaper|S000069994}} PMID 12067726</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR153W:''' Short-lived membrane ABC (ATP-binding cassette) transporter, actively exports various drugs, expression regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72
+'''Description of YOR153W:''' Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth<ref name='S000075843'>Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 {{SGDpaper|S000075843}} PMID 14960317</ref><ref name='S000069994'>Emter R, et al. (2002) ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521(1-3):57-61 {{SGDpaper|S000069994}} PMID 12067726</ref><ref name='S000060194'>Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14 {{SGDpaper|S000060194}} PMID 11321575</ref><ref name='S000052729'>Egner R and Kuchler K (1996) The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378(2):177-81 {{SGDpaper|S000052729}} PMID 8549828</ref><ref name='S000043769'>Egner R, et al. (1995) Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol 15(11):5879-87 {{SGDpaper|S000043769}} PMID 7565740</ref><ref name='S000042972'>Bissinger PH and Kuchler K (1994) Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance. J Biol Chem 269(6):4180-6 {{SGDpaper|S000042972}} PMID 8307980</ref><ref name='S000042556'>Miyahara K, et al. (1996) The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance. FEBS Lett 399(3):317-20 {{SGDpaper|S000042556}} PMID 8985171</ref><ref name='S000042040'>Balzi E, et al. (1994) PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J Biol Chem 269(3):2206-14 {{SGDpaper|S000042040}} PMID 8294477</ref><ref name='S000040660'>Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72
   {{SGDpaper|S000040660}} PMID 8810273</ref>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005679 YOR153W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005679 YOR153W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''PDR5 ''

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 {{PageTop}}
 {|{{Prettytable}} align = 'right' width = '200px'
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:619841..624376
 |}
 <br>
@@ Line 23: / Line 22: @@
 <br>
 <br>
+<br>
 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}