YOR076C - Revision history

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{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOR076C YOR076C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SKI7 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''YOR29-27''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:471622..469379
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Antiviral adaptor protein that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs<ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000054260'>Ridley SP, et al. (1984) Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN. Mol Cell Biol 4(4):761-70 {{SGDpaper|S000054260}} PMID 6371496</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000042674'>Peltz SW, et al. (1999) Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol 19(1):384-91
{{SGDpaper|S000042674}} PMID 9858562</ref>
 
 
 
 

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==Community Commentary==
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==References==

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@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:471622..469379
+|nowrap| Chr XV:471620..469377
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005602

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR076C:''' Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype<ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4
+'''Description of YOR076C:''' Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype<ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4
   {{SGDpaper|S000069566}} PMID 11910110</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR076C:''' Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype<ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900
+'''Description of YOR076C:''' Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype<ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4
-  {{SGDpaper|S000052117}} PMID 10074137</ref>
+  {{SGDpaper|S000069566}} PMID 11910110</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR076C:''' Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs<ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000042674'>Peltz SW, et al. (1999) Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol 19(1):384-91
+'''Description of YOR076C:''' Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype<ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900
- {{SGDpaper|S000042674}} PMID 9858562</ref>
+ {{SGDpaper|S000052117}} PMID 10074137</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOR076C:''' Antiviral adaptor protein that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs<ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000054260'>Ridley SP, et al. (1984) Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN. Mol Cell Biol 4(4):761-70 {{SGDpaper|S000054260}} PMID 6371496</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000042674'>Peltz SW, et al. (1999) Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol 19(1):384-91
+'''Description of YOR076C:''' Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs<ref name='S000086198'>Wang L, et al. (2005) Domain interactions within the Ski2/3/8 complex and between the Ski complex and Ski7p. RNA 11(8):1291-302 {{SGDpaper|S000086198}} PMID 16043509</ref><ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000069566'>van Hoof A, et al. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295(5563):2262-4 {{SGDpaper|S000069566}} PMID 11910110</ref><ref name='S000066048'>Araki Y, et al. (2001) Ski7p G protein interacts with the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast. EMBO J 20(17):4684-93 {{SGDpaper|S000066048}} PMID 11532933</ref><ref name='S000059193'>van Hoof A, et al. (2000) Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol 20(21):8230-43 {{SGDpaper|S000059193}} PMID 11027292</ref><ref name='S000052117'>Benard L, et al. (1999) The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae. J Virol 73(4):2893-900 {{SGDpaper|S000052117}} PMID 10074137</ref><ref name='S000042674'>Peltz SW, et al. (1999) Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol 19(1):384-91
   {{SGDpaper|S000042674}} PMID 9858562</ref>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005602 YOR076C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005602 YOR076C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SKI7 ''

← Older revision		Revision as of 20:02, 21 February 2007
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		+
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

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 {|{{Prettytable}} align = 'right' width = '200px'
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:471622..469379
 |}
 <br>
@@ Line 23: / Line 22: @@
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+<br>
 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}