YOR008C - Revision history

Timlevine: /* Community Commentary */

2013-03-21T16:14:45Z

‎Community Commentary

Timlevine at 15:58, 21 March 2013

2013-03-21T15:58:29Z

Timlevine at 15:43, 21 March 2013

2013-03-21T15:43:14Z

Timlevine: /* Community Commentary */

2013-03-21T15:40:33Z

‎Community Commentary

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 {{CommentaryHelp}}
-==
+== Transmembrane Domain GxxxG  ==
 The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple, overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Slg1p/Wsc1p multimerises.

← Older revision		Revision as of 15:58, 21 March 2013
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	Transmembrane Domain GxxxG ==		Transmembrane Domain GxxxG ==

−	The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Slg1p/Wsc1p multimerises.	+	The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple, overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Slg1p/Wsc1p multimerises.

← Older revision		Revision as of 15:43, 21 March 2013
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	{{CommentaryHelp}}		{{CommentaryHelp}}

		+	==
		+	Transmembrane Domain GxxxG ==
		+
		+	The transmembrane domain of Slg1p/Wsc1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with vGaivGGvvGGvvG. The presence of multiple overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Slg1p/Wsc1p multimerises.

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 <protect>
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005534 YOR008C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005534 YOR008C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SLG1 ''

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 |}
 <br>
-'''Description of YOR008C:''' Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response<ref name='S000077490'>Gualtieri T, et al. (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20 {{SGDpaper|S000077490}} PMID 15484288</ref><ref name='S000039898'>Lodder AL, et al. (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99 {{SGDpaper|S000039898}} PMID 10430578</ref><ref name='S000077921'>Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
+'''Description of YOR008C:''' Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response<ref name='S000077490'>Gualtieri T, et al. (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20 {{SGDpaper|S000077490}} PMID 15484288</ref><ref name='S000039898'>Lodder AL, et al. (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99 {{SGDpaper|S000039898}} PMID 10430578</ref><ref name='S000145416'>Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67 {{SGDpaper|S000145416}} PMID 21576396</ref><ref name='S000077921'>Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
   {{SGDpaper|S000077921}} PMID 11545731</ref>
 <br>

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 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:342415..341279
+|nowrap| Chr XV:342414..341278
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005534