YOL027C - Revision history

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{|{{Prettytable}} align = 'right' width = '200px'
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOL027C YOL027C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''MDM38 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''MKH1''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:273725..272004
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Mitochondrial inner membrane protein, required for K+/H+ exchange and for normal mitochondrial morphology and inheritance; associates with mitochondrial ribosomes; human ortholog Letm1 is implicated in Wolf-Hirschhorn syndrome<ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
{{SGDpaper|S000071517}} PMID 11907266</ref>
 
 
 
 

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==Community Commentary==
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==References==

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 <br>
-'''Description of YOL027C:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53 {{SGDpaper|S000071517}} PMID 11907266</ref><ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15
+'''Description of YOL027C:''' Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000136876'>Bauerschmitt H, et al. (2010) Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell 21(12):1937-44 {{SGDpaper|S000136876}} PMID 20427570</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53 {{SGDpaper|S000071517}} PMID 11907266</ref><ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15
   {{SGDpaper|S000076911}} PMID 15138253</ref>
 <br>

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:273725..272004
+|nowrap| Chr XV:273724..272003
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005387

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOL027C:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
+'''Description of YOL027C:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53 {{SGDpaper|S000071517}} PMID 11907266</ref><ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15
-  {{SGDpaper|S000071517}} PMID 11907266</ref>
+  {{SGDpaper|S000076911}} PMID 15138253</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOL027C:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
+'''Description of YOL027C:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
   {{SGDpaper|S000071517}} PMID 11907266</ref>
 <br>

@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOL027C YOL027C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005387 YOL027C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''MDM38 ''
@@ Line 14: / Line 14: @@
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:273725..272004
 |}
 <br>
-'''Description of {{PAGENAME}}:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
+'''Description of YOL027C:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
   {{SGDpaper|S000071517}} PMID 11907266</ref>
 <br>
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 J Biol Chem 278(5):3265-74</ref>
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 |}
 <br>
-'''Description of {{PAGENAME}}:''' Mitochondrial inner membrane protein, required for K+/H+ exchange and for normal mitochondrial morphology and inheritance; associates with mitochondrial ribosomes; human ortholog Letm1 is implicated in Wolf-Hirschhorn syndrome<ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
+'''Description of {{PAGENAME}}:''' Mitochondrial inner membrane protein, involved in membrane integration of a subset of mitochondrial proteins; required for K+/H+ exchange; associates with mitochondrial ribosomes; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome<ref name='S000114395'>Frazier AE, et al. (2006) Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol 172(4):553-64 {{SGDpaper|S000114395}} PMID 16476776</ref><ref name='S000082022'>Froschauer E, et al. (2005) Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins. Biochim Biophys Acta 1711(1):41-8 {{SGDpaper|S000082022}} PMID 15904662</ref><ref name='S000076911'>Nowikovsky K, et al. (2004) The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome. J Biol Chem 279(29):30307-15 {{SGDpaper|S000076911}} PMID 15138253</ref><ref name='S000071517'>Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
   {{SGDpaper|S000071517}} PMID 11907266</ref>
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:273725..272004
 |}
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 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
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 {{RefHelp}}