YOL025W - Revision history

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005385 YOL025W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005385 YOL025W]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''LAG2 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:274958..276940
+|nowrap| Chr XV:274957..276939
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005385

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 |}
 <br>
-'''Description of YOL025W:''' Protein involved in the determination of longevity and in the negative regulation of SCF E3-ubiquitin ligase function; preferentially expressed in young cells; overexpression extends replicative life span; similar to mammalian Cand1<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 {{SGDpaper|S000131589}} PMID 19763088</ref><ref name='S000132362'>Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56
+'''Description of YOL025W:''' Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 {{SGDpaper|S000131589}} PMID 19763088</ref><ref name='S000132362'>Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56
   {{SGDpaper|S000132362}} PMID 19942853</ref>
 <br>

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 |}
 <br>
-'''Description of YOL025W:''' Protein involved in the determination of longevity and also in the negative regulation of SCF E3-ubiquitin ligase function; LAG2 is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77
+'''Description of YOL025W:''' Protein involved in the determination of longevity and in the negative regulation of SCF E3-ubiquitin ligase function; preferentially expressed in young cells; overexpression extends replicative life span; similar to mammalian Cand1<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77 {{SGDpaper|S000131589}} PMID 19763088</ref><ref name='S000132362'>Siergiejuk E, et al. (2009) Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28(24):3845-56
-  {{SGDpaper|S000131589}} PMID 19763088</ref>
+  {{SGDpaper|S000132362}} PMID 19942853</ref>
 <br>
 <br>

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 |}
 <br>
-'''Description of YOL025W:''' Protein involved in the determination of longevity and also in the negative regulation of SCF E3-ubiquitin ligase function; LAG2 is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J
+'''Description of YOL025W:''' Protein involved in the determination of longevity and also in the negative regulation of SCF E3-ubiquitin ligase function; LAG2 is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells<ref name='S000055741'>Childress AM, et al. (1996) LAG2, a gene that determines yeast longevity. Microbiology 142 ( Pt 8):2289-97 {{SGDpaper|S000055741}} PMID 8760941</ref><ref name='S000131589'>Liu Y, et al. (2009) A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. EMBO J 28(21):3366-77
   {{SGDpaper|S000131589}} PMID 19763088</ref>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:274958..276940
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 ==Community Commentary==
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