YOL013C - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YOL013C YOL013C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HRD1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''DER3''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XV:303036..301381
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger<ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82 {{SGDpaper|S000063522}} PMID 11018054</ref><ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44 {{SGDpaper|S000048185}} PMID 8970163</ref><ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22
{{SGDpaper|S000044060}} PMID 9437001</ref>
 
 
 
 

__TOC__
==Community Commentary==
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==References==

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@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOL013C:''' Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger<ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22 {{SGDpaper|S000044060}} PMID 9437001</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82 {{SGDpaper|S000063522}} PMID 11018054</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44
+'''Description of YOL013C:''' Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon<ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22 {{SGDpaper|S000044060}} PMID 9437001</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82 {{SGDpaper|S000063522}} PMID 11018054</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44 {{SGDpaper|S000048185}} PMID 8970163</ref><ref name='S000149792'>Rubenstein EM, et al. (2012) Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. J Cell Biol 197(6):761-73
-  {{SGDpaper|S000048185}} PMID 8970163</ref>
+  {{SGDpaper|S000149792}} PMID 22689655</ref>
 <br>
 <br>

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XV:303036..301381
+|nowrap| Chr XV:303035..301380
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000005373

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOL013C:''' Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger<ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22 {{SGDpaper|S000044060}} PMID 9437001</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44 {{SGDpaper|S000048185}} PMID 8970163</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82
+'''Description of YOL013C:''' Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger<ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22 {{SGDpaper|S000044060}} PMID 9437001</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82 {{SGDpaper|S000063522}} PMID 11018054</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44
-  {{SGDpaper|S000063522}} PMID 11018054</ref>
+  {{SGDpaper|S000048185}} PMID 8970163</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YOL013C:''' Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger<ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82 {{SGDpaper|S000063522}} PMID 11018054</ref><ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44 {{SGDpaper|S000048185}} PMID 8970163</ref><ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22
+'''Description of YOL013C:''' Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger<ref name='S000044060'>Bordallo J, et al. (1998) Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9(1):209-22 {{SGDpaper|S000044060}} PMID 9437001</ref><ref name='S000048185'>Hampton RY, et al. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44 {{SGDpaper|S000048185}} PMID 8970163</ref><ref name='S000054799'>Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 {{SGDpaper|S000054799}} PMID 10878801</ref><ref name='S000060383'>Deak PM and Wolf DH (2001) Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276(14):10663-9 {{SGDpaper|S000060383}} PMID 11139575</ref><ref name='S000060764'>Bays NW, et al. (2001) Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3(1):24-9 {{SGDpaper|S000060764}} PMID 11146622</ref><ref name='S000063522'>Gardner RG, et al. (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82
-  {{SGDpaper|S000044060}} PMID 9437001</ref>
+  {{SGDpaper|S000063522}} PMID 11018054</ref>
 <br>
 <br>

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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005373 YOL013C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005373 YOL013C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''HRD1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XV:303036..301381
 |}
 <br>
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 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}