YNL298W - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YNL298W YNL298W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CLA4 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''ERC10''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XIV:68915..71443
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p<ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76
{{SGDpaper|S000055422}} PMID 9271384</ref>
 
 
 
 

__TOC__
==Community Commentary==
{{CommentaryHelp}}

==References==

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@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p<ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 {{SGDpaper|S000129348}} PMID 19218422</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15
+'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p<ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 {{SGDpaper|S000129348}} PMID 19218422</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000131819'>Lin M, et al. (2009) The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway. Mol Biol Cell 20(22):4826-37 {{SGDpaper|S000131819}} PMID 19793923</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15
   {{SGDpaper|S000077127}} PMID 14993234</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p<ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72
+'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p<ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72 {{SGDpaper|S000129348}} PMID 19218422</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15
- {{SGDpaper|S000129348}} PMID 19218422</ref>
+ {{SGDpaper|S000077127}} PMID 14993234</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p<ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000129348'>Bartholomew CR and Hardy CF (2009) The p21-Activated Kinases Cla4 and Ste20 Regulate Vacuole Inheritance in S. cerevisiae. Eukaryot Cell
+'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p<ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000129348'>Bartholomew CR and Hardy CF (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72
   {{SGDpaper|S000129348}} PMID 19218422</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YNL298W:''' Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p<ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66
+'''Description of YNL298W:''' Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p<ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000129348'>Bartholomew CR and Hardy CF (2009) The p21-Activated Kinases Cla4 and Ste20 Regulate Vacuole Inheritance in S. cerevisiae. Eukaryot Cell
-  {{SGDpaper|S000074263}} PMID 14517318</ref>
+  {{SGDpaper|S000129348}} PMID 19218422</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YNL298W:''' Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p<ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76
+'''Description of YNL298W:''' Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p<ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76 {{SGDpaper|S000055422}} PMID 9271384</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66
-  {{SGDpaper|S000055422}} PMID 9271384</ref>
+  {{SGDpaper|S000074263}} PMID 14517318</ref>
 <br>
 <br>

@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005242 YNL298W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005242 YNL298W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''CLA4 ''

@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YNL298W YNL298W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005242 YNL298W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''CLA4 ''
@@ Line 14: / Line 14: @@
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XIV:68915..71443
 |}
 <br>
-'''Description of {{PAGENAME}}:''' Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p<ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76
+'''Description of YNL298W:''' Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p<ref name='S000077127'>Versele M and Thorner J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J Cell Biol 164(5):701-15 {{SGDpaper|S000077127}} PMID 14993234</ref><ref name='S000074263'>Caviston JP, et al. (2003) The role of Cdc42p GTPase-activating proteins in assembly of the septin ring in yeast. Mol Biol Cell 14(10):4051-66 {{SGDpaper|S000074263}} PMID 14517318</ref><ref name='S000057413'>Cvrckova F, et al. (1995) Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev 9(15):1817-30 {{SGDpaper|S000057413}} PMID 7649470</ref><ref name='S000055422'>Benton BK, et al. (1997) Cla4p, a Saccharomyces cerevisiae Cdc42p-activated kinase involved in cytokinesis, is activated at mitosis. Mol Cell Biol 17(9):5067-76
   {{SGDpaper|S000055422}} PMID 9271384</ref>
 <br>
@@ Line 37: / Line 39: @@
 J Biol Chem 278(5):3265-74</ref>
 -->
 <protect>

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XIV:68915..71443
 |}
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+<br>
 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}