YNL283C - Revision history

Timlevine at 16:14, 21 March 2013

2013-03-21T16:14:41Z

Timlevine at 16:05, 21 March 2013

2013-03-21T16:05:02Z

Timlevine at 16:03, 21 March 2013

2013-03-21T16:03:04Z

Timlevine at 16:02, 21 March 2013

2013-03-21T16:02:23Z

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 {{CommentaryHelp}}
-==
+== Transmembrane Domain GxxxG  ==
 The transmembrane domain of Wsc2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with GlsgGaiaGvvvGvvcG. The presence of multiple, overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that wsc2 multimerises.

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 ==Community Commentary==
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 ==Community Commentary==
 == Transmembrane Domain GxxxG ==
-The transmembrane domain of Wsc2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with GlsgGaiaGvvvGvvcG The presence of multiple overlapping GxxxG motifs [5] strongly indicates that wsc2p multimerises.
+<== Transmembrane Domain GxxxG ==
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 ==Community Commentary==
 == Transmembrane Domain GxxxG ==
 The transmembrane domain of Wsc2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with GlsgGaiaGvvvGvvcG The presence of multiple overlapping GxxxG motifs [5] strongly indicates that wsc2p multimerises.

← Older revision		Revision as of 16:01, 21 March 2013
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	==Community Commentary==		==Community Commentary==
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		+	== Transmembrane Domain GxxxG ==
		+	The transmembrane domain of Wsc2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with GlsgGaiaGvvvGvvcG The presence of multiple overlapping GxxxG motifs [5] strongly indicates that wsc2p multimerises.

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005227 YNL283C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005227 YNL283C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''WSC2 ''

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 |}
 <br>
-'''Description of YNL283C:''' Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response<ref name='S000043525'>Raboy B, et al. (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39 {{SGDpaper|S000043525}} PMID 10361277</ref><ref name='S000048928'>Verna J, et al. (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9 {{SGDpaper|S000048928}} PMID 9391108</ref><ref name='S000061288'>Kosodo Y, et al. (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14 {{SGDpaper|S000061288}} PMID 11481671</ref><ref name='S000077921'>Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 {{SGDpaper|S000077921}} PMID 11545731</ref><ref name='S000066017'>Zu T, et al. (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55 {{SGDpaper|S000066017}} PMID 11589572</ref><ref name='S000082119'>Imazu H and Sakurai H (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6 {{SGDpaper|S000082119}} PMID 15947197</ref><ref name='S000078594'>Ng DT (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20
+'''Description of YNL283C:''' Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response<ref name='S000082119'>Imazu H and Sakurai H (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6 {{SGDpaper|S000082119}} PMID 15947197</ref><ref name='S000061288'>Kosodo Y, et al. (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14 {{SGDpaper|S000061288}} PMID 11481671</ref><ref name='S000077921'>Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 {{SGDpaper|S000077921}} PMID 11545731</ref><ref name='S000078594'>Ng DT (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20 {{SGDpaper|S000078594}} PMID 11702943</ref><ref name='S000043525'>Raboy B, et al. (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39 {{SGDpaper|S000043525}} PMID 10361277</ref><ref name='S000048928'>Verna J, et al. (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9 {{SGDpaper|S000048928}} PMID 9391108</ref><ref name='S000066017'>Zu T, et al. (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55
-  {{SGDpaper|S000078594}} PMID 11702943</ref>
+  {{SGDpaper|S000066017}} PMID 11589572</ref>
 <br>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YNL283C YNL283C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000005227 YNL283C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''WSC2 ''
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XIV:106695..105184
 |}
 <br>
-'''Description of {{PAGENAME}}:''' Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response<ref name='S000082119'>Imazu H and Sakurai H (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6 {{SGDpaper|S000082119}} PMID 15947197</ref><ref name='S000078594'>Ng DT (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20 {{SGDpaper|S000078594}} PMID 11702943</ref><ref name='S000077921'>Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 {{SGDpaper|S000077921}} PMID 11545731</ref><ref name='S000066017'>Zu T, et al. (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55 {{SGDpaper|S000066017}} PMID 11589572</ref><ref name='S000061288'>Kosodo Y, et al. (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14 {{SGDpaper|S000061288}} PMID 11481671</ref><ref name='S000048928'>Verna J, et al. (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9 {{SGDpaper|S000048928}} PMID 9391108</ref><ref name='S000043525'>Raboy B, et al. (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39
+'''Description of YNL283C:''' Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response<ref name='S000082119'>Imazu H and Sakurai H (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6 {{SGDpaper|S000082119}} PMID 15947197</ref><ref name='S000078594'>Ng DT (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20 {{SGDpaper|S000078594}} PMID 11702943</ref><ref name='S000077921'>Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 {{SGDpaper|S000077921}} PMID 11545731</ref><ref name='S000066017'>Zu T, et al. (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55 {{SGDpaper|S000066017}} PMID 11589572</ref><ref name='S000061288'>Kosodo Y, et al. (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14 {{SGDpaper|S000061288}} PMID 11481671</ref><ref name='S000048928'>Verna J, et al. (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9 {{SGDpaper|S000048928}} PMID 9391108</ref><ref name='S000043525'>Raboy B, et al. (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39
   {{SGDpaper|S000043525}} PMID 10361277</ref>
 <br>
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 J Biol Chem 278(5):3265-74</ref>
 -->
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← Older revision		Revision as of 20:02, 21 February 2007
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		+
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		+
		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

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