YMR217W - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YMR217W YMR217W]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''GUA1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XIII:701789..703366
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation<ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 {{SGDpaper|S000074047}} PMID 12917348</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9 {{SGDpaper|S000061036}} PMID 222417</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32
{{SGDpaper|S000041905}} PMID 8112582</ref>
 
 
 
 

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==Community Commentary==
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==References==

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@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YMR217W:''' GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation<ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32 {{SGDpaper|S000041905}} PMID 8112582</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 {{SGDpaper|S000074047}} PMID 12917348</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9
+'''Description of YMR217W:''' GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA<ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32 {{SGDpaper|S000041905}} PMID 8112582</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 {{SGDpaper|S000074047}} PMID 12917348</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9 {{SGDpaper|S000061036}} PMID 222417</ref><ref name='S000139076'>Iglesias-Gato D, et al. (2011) Guanine Nucleotide Pool Imbalance Impairs Multiple Steps of Protein Synthesis and Disrupts GCN4 Translational Control in Saccharomyces cerevisiae. Genetics 187(1):105-22
-  {{SGDpaper|S000061036}} PMID 222417</ref>
+  {{SGDpaper|S000139076}} PMID 20980241</ref>
 <br>
 <br>

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XIII:701789..703366
+|nowrap| Chr XIII:701790..703367
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000004830

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YMR217W:''' GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation<ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32 {{SGDpaper|S000041905}} PMID 8112582</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9 {{SGDpaper|S000061036}} PMID 222417</ref><ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90
+'''Description of YMR217W:''' GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation<ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32 {{SGDpaper|S000041905}} PMID 8112582</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 {{SGDpaper|S000074047}} PMID 12917348</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9
-  {{SGDpaper|S000074047}} PMID 12917348</ref>
+  {{SGDpaper|S000061036}} PMID 222417</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YMR217W:''' GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation<ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90 {{SGDpaper|S000074047}} PMID 12917348</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9 {{SGDpaper|S000061036}} PMID 222417</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32
+'''Description of YMR217W:''' GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation<ref name='S000041905'>Dujardin G, et al. (1994) Cloning and sequencing of the GMP synthetase-encoding gene of Saccharomyces cerevisiae. Gene 139(1):127-32 {{SGDpaper|S000041905}} PMID 8112582</ref><ref name='S000060059'>Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30 {{SGDpaper|S000060059}} PMID 11035032</ref><ref name='S000061036'>Gardner WJ and Woods RA (1979) Isolation and characterisation of guanine auxotrophs in Saccharomyces cerevisiae. Can J Microbiol 25(3):380-9 {{SGDpaper|S000061036}} PMID 222417</ref><ref name='S000074047'>Escobar-Henriques M, et al. (2003) Transcription initiation of the yeast IMD2 gene is abolished in response to nutrient limitation through a sequence in its coding region. Mol Cell Biol 23(17):6279-90
-  {{SGDpaper|S000041905}} PMID 8112582</ref>
+  {{SGDpaper|S000074047}} PMID 12917348</ref>
 <br>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004830 YMR217W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004830 YMR217W]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''GUA1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XIII:701789..703366
 |}
 <br>
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 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}