YML125C - Revision history

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← Older revision		Revision as of 21:50, 19 October 2012
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−	YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, '''N'''ADH ubi'''Q'''uinone '''R'''eductase 1 (~~Carletrix~~, personal communication)	+	YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, '''N'''ADH ubi'''Q'''uinone '''R'''eductase 1 (Carlos Santos-Ocana, personal communication)

← Older revision		Revision as of 21:45, 19 October 2012
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−	YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, ~~NADH ubiQuinone Reductase~~ 1	+	YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, '''N'''ADH ubi'''Q'''uinone '''R'''eductase 1 (Carletrix, personal communication)

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-YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, '''N'''ADH ubi'''Q'''uinone '''R'''eductase 1 (Carlos Santos-Ocana, personal communication)
+YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, NADH ubiQuinone Reductase 1
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+YML125c gene is a plasma membrane NADH-ubiquinone reductase and belongs to the family of cytochrome b5 reductases. Its activity is absolutely dependent of NADH as electron donor and in vivo and in vitro reduce the plasma membrane ubiquinone. The ubiquinone reduction is produced using the one-electron way that involved the superoxide production and is inhibited by DPI, a potent inhibitor of flavodehydrogeneses. Although the null mutant is lethal, the YML125c over expression produces an increased life span extension. We propose the name NQR1 for this gene, '''N'''ADH ubi'''Q'''uinone '''R'''eductase 1 (Carlos Santos-Ocana, personal communication)
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 {|{{Prettytable}} align = 'right' width = '200px'
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-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004594 YML125C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004594 YML125C]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''PGA3 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XIII:21700..20762
+|nowrap| Chr XIII:21699..20761
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000004594

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-'''Description of YML125C:''' Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking<ref name='S000118289'>Yu L, et al. (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47 {{SGDpaper|S000118289}} PMID 16943325</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000129421'>Jimenez-Hidalgo M, et al. (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51
+'''Description of YML125C:''' Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking<ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000129421'>Jimenez-Hidalgo M, et al. (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51 {{SGDpaper|S000129421}} PMID 19239415</ref><ref name='S000118289'>Yu L, et al. (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47
-  {{SGDpaper|S000129421}} PMID 19239415</ref>
+  {{SGDpaper|S000118289}} PMID 16943325</ref>
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