YLR186W - Revision history

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-'''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome<ref name='S000150432'>Armistead J, et al. (2009) Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet 84(6):728-39 {{SGDpaper|S000150432}} PMID 19463982</ref><ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
+'''Description of YLR186W:''' Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity<ref name='S000150432'>Armistead J, et al. (2009) Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet 84(6):728-39 {{SGDpaper|S000150432}} PMID 19463982</ref><ref name='S000116009'>Buchhaupt M, et al. (2006) Genetic evidence for 18S rRNA binding and an Rps19p assembly function of yeast nucleolar protein Nep1p. Mol Genet Genomics 276(3):273-84 {{SGDpaper|S000116009}} PMID 16721597</ref><ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000151058'>Meyer B, et al. (2011) The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA. Nucleic Acids Res 39(4):1526-37
-  {{SGDpaper|S000074191}} PMID 14566057</ref>
+  {{SGDpaper|S000151058}} PMID 20972225</ref>
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 |}
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-'''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers<ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
+'''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome<ref name='S000150432'>Armistead J, et al. (2009) Mutation of a gene essential for ribosome biogenesis, EMG1, causes Bowen-Conradi syndrome. Am J Hum Genet 84(6):728-39 {{SGDpaper|S000150432}} PMID 19463982</ref><ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
   {{SGDpaper|S000074191}} PMID 14566057</ref>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004176 YLR186W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004176 YLR186W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''EMG1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XII:523634..524392
+|nowrap| Chr XII:523632..524390
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000004176

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers<ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83 {{SGDpaper|S000074191}} PMID 14566057</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39
+'''Description of YLR186W:''' Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers<ref name='S000069531'>Eschrich D, et al. (2002) Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis. Curr Genet 40(5):326-38 {{SGDpaper|S000069531}} PMID 11935223</ref><ref name='S000124903'>Leulliot N, et al. (2008) The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. Nucleic Acids Res 36(2):629-39 {{SGDpaper|S000124903}} PMID 18063569</ref><ref name='S000066272'>Liu PC and Thiele DJ (2001) Novel stress-responsive genes EMG1 and NOP14 encode conserved, interacting proteins required for 40S ribosome biogenesis. Mol Biol Cell 12(11):3644-57 {{SGDpaper|S000066272}} PMID 11694595</ref><ref name='S000074191'>Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
-  {{SGDpaper|S000124903}} PMID 18063569</ref>
+  {{SGDpaper|S000074191}} PMID 14566057</ref>
 <br>
 <br>

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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XII:523634..524392
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 ==Community Commentary==
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