YLR079W - Revision history

SGDwikiBot: Automated import of articles

2012-04-26T21:05:19Z

Automated import of articles

SGDwikiBot: Automated import of articles

2012-01-23T14:45:34Z

Automated import of articles

SGDwikiBot: Automated import of articles

2011-02-03T21:05:31Z

Automated import of articles

SGDwikiBot: Automated import of articles

2010-02-25T21:05:25Z

Automated import of articles

SGDwikiBot: Automated import of articles

2009-03-31T21:05:28Z

Automated import of articles

SGDwikiBot: Automated import of articles

2007-02-27T15:46:12Z

Automated import of articles

SGDwikiBot: Automated import of articles

2007-02-21T20:02:19Z

Automated import of articles

SGDwikiBot: Automated import of articles

2007-01-30T15:18:02Z

Automated import of articles

SGDwikiBot: Automated import of articles

2007-01-24T18:51:41Z

Automated import of articles

SGDwikiBot: Automated import of articles

2007-01-24T00:05:38Z

Automated import of articles

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 {{SGDpaper|S000041398}} PMID 9346239</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 {{SGDpaper|S000074398}} PMID 11734846</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60
+'''Description of YLR079W:''' Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 {{SGDpaper|S000041398}} PMID 9346239</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 {{SGDpaper|S000074398}} PMID 11734846</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60
   {{SGDpaper|S000062149}} PMID 9334303</ref>
 <br>

@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004069 YLR079W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000004069 YLR079W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SIC1 ''

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XII:286821..287675
+|nowrap| Chr XII:286820..287674
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000004069

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 {{SGDpaper|S000041398}} PMID 9346239</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 {{SGDpaper|S000062149}} PMID 9334303</ref><ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21
+'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 {{SGDpaper|S000041398}} PMID 9346239</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 {{SGDpaper|S000074398}} PMID 11734846</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60
- {{SGDpaper|S000074398}} PMID 11734846</ref>
+ {{SGDpaper|S000062149}} PMID 9334303</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21 {{SGDpaper|S000074398}} PMID 11734846</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 {{SGDpaper|S000062149}} PMID 9334303</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30
+'''Description of YLR079W:''' Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1<ref name='S000041398'>Feldman RM, et al. (1997) A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell 91(2):221-30 {{SGDpaper|S000041398}} PMID 9346239</ref><ref name='S000043548'>Schwob E, et al. (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44 {{SGDpaper|S000043548}} PMID 7954792</ref><ref name='S000045057'>Nugroho TT and Mendenhall MD (1994) An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic integrity of daughter cells. Mol Cell Biol 14(5):3320-8 {{SGDpaper|S000045057}} PMID 8164683</ref><ref name='S000050766'>Donovan JD, et al. (1994) P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae. Genes Dev 8(14):1640-53 {{SGDpaper|S000050766}} PMID 7958845</ref><ref name='S000057743'>Mendenhall MD (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9 {{SGDpaper|S000057743}} PMID 8421781</ref><ref name='S000058226'>Skowyra D, et al. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91(2):209-19 {{SGDpaper|S000058226}} PMID 9346238</ref><ref name='S000062149'>Verma R, et al. (1997) Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science 278(5337):455-60 {{SGDpaper|S000062149}} PMID 9334303</ref><ref name='S000080407'>Barberis M, et al. (2005) The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J 387(Pt 3):639-47 {{SGDpaper|S000080407}} PMID 15649124</ref><ref name='S000074398'>Nash P, et al. (2001) Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414(6863):514-21
-  {{SGDpaper|S000041398}} PMID 9346239</ref>
+  {{SGDpaper|S000074398}} PMID 11734846</ref>
 <br>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
Line 36:		Line 36:

	{{ShortCenteredHR}}		{{ShortCenteredHR}}
		+
		+
		+
		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

@@ Line 1: / Line 1: @@
 <!-- PLEASE DO NOT EDIT HERE. USE THE SECTION EDIT LINKS ON THE RIGHT MARGIN-->
 {{PageTop}}
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
@@ Line 13: / Line 14: @@
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XII:286821..287675
 |}
 <br>
@@ Line 23: / Line 22: @@
 <br>
 <br>
 __TOC__
 ==Community Commentary==
@@ Line 35: / Line 36: @@
 {{ShortCenteredHR}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}