YLR008C - Revision history

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2011-02-03T21:05:31Z

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2009-02-26T14:21:40Z

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2007-02-27T15:46:11Z

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2007-02-21T20:02:19Z

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003998 YLR008C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003998 YLR008C]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''PAM18 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XII:166082..165576
+|nowrap| Chr XII:166083..165577
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003998

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 |}
 <br>
-'''Description of YLR008C:''' Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p<ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85
+'''Description of YLR008C:''' Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p<ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 {{SGDpaper|S000120441}} PMID 16977310</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13
-  {{SGDpaper|S000120441}} PMID 16977310</ref>
+  {{SGDpaper|S000074354}} PMID 14638855</ref>
 <br>
 <br>

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 |}
 <br>
-'''Description of YLR008C:''' Conserved, essential J-protein cochaperone, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); stimulates ATPase activity of Ssc1p to drive import; inhibited by Pam16p<ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85
+'''Description of YLR008C:''' Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p<ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85
   {{SGDpaper|S000120441}} PMID 16977310</ref>
 <br>

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 |}
 <br>
-'''Description of YLR008C:''' J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p<ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85
+'''Description of YLR008C:''' Conserved, essential J-protein cochaperone, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); stimulates ATPase activity of Ssc1p to drive import; inhibited by Pam16p<ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56 {{SGDpaper|S000074353}} PMID 14517234</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85
   {{SGDpaper|S000120441}} PMID 16977310</ref>
 <br>

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 |}
 <br>
-'''Description of {{PAGENAME}}:''' Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain<ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56
+'''Description of {{PAGENAME}}:''' J-protein constituent of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p<ref name='S000120441'>Mokranjac D, et al. (2006) Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. EMBO J 25(19):4675-85 {{SGDpaper|S000120441}} PMID 16977310</ref><ref name='S000075099'>D'Silva PD, et al. (2003) J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix. Proc Natl Acad Sci U S A 100(24):13839-44 {{SGDpaper|S000075099}} PMID 14605210</ref><ref name='S000074354'>Truscott KN, et al. (2003) A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria. J Cell Biol 163(4):707-13 {{SGDpaper|S000074354}} PMID 14638855</ref><ref name='S000074353'>Mokranjac D, et al. (2003) Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria. EMBO J 22(19):4945-56
   {{SGDpaper|S000074353}} PMID 14517234</ref>
 <br>
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XII:166082..165576
 |}
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 ==Community Commentary==
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 ==References==
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