YLL050C - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YLL050C YLL050C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''COF1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XII:40413..39803
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes<ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32 {{SGDpaper|S000062354}} PMID 9753544</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35
{{SGDpaper|S000039142}} PMID 8421056</ref>
 
 
 
 

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==Community Commentary==
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==References==

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@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr XII:40413..39803
+|nowrap| Chr XII:40414..39804
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003973

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes<ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35 {{SGDpaper|S000039142}} PMID 8421056</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32
+'''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes<ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35 {{SGDpaper|S000039142}} PMID 8421056</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32
   {{SGDpaper|S000062354}} PMID 9753544</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes<ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32 {{SGDpaper|S000062354}} PMID 9753544</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35
+'''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes<ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35 {{SGDpaper|S000039142}} PMID 8421056</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32
-  {{SGDpaper|S000039142}} PMID 8421056</ref>
+  {{SGDpaper|S000062354}} PMID 9753544</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments , thought to be regulated by phosphorylation at SER4, ubiquitous and essential in eukaryotes<ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32 {{SGDpaper|S000062354}} PMID 9753544</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35
+'''Description of YLL050C:''' Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes<ref name='S000062354'>Wriggers W, et al. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode. J Mol Biol 282(5):921-32 {{SGDpaper|S000062354}} PMID 9753544</ref><ref name='S000058067'>Theriot JA (1997) Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton. J Cell Biol 136(6):1165-8 {{SGDpaper|S000058067}} PMID 9087434</ref><ref name='S000056079'>Moriyama K, et al. (1996) Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells 1(1):73-86 {{SGDpaper|S000056079}} PMID 9078368</ref><ref name='S000047128'>Iida K, et al. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein. Gene 124(1):115-20 {{SGDpaper|S000047128}} PMID 8440472</ref><ref name='S000044417'>Ayscough KR, et al. (1997) High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A. J Cell Biol 137(2):399-416 {{SGDpaper|S000044417}} PMID 9128251</ref><ref name='S000039142'>Moon AL, et al. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton. J Cell Biol 120(2):421-35
   {{SGDpaper|S000039142}} PMID 8421056</ref>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003973 YLL050C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003973 YLL050C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''COF1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr XII:40413..39803
 |}
 <br>
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+<br>
 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}