YJR060W - Revision history

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2007-02-27T15:46:11Z

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@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003821 YJR060W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003821 YJR060W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''CBF1 ''

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJR060W:''' Helix-loop-helix trasnscription factor; binds the motif CACRTG which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA; competes with Pho4p DNA binding motif and there by helps define the specificity of Pho4p gene regulation<ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 {{SGDpaper|S000059050}} PMID 15111622</ref><ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 {{SGDpaper|S000059647}} PMID 11222754</ref><ref name='S000145916'>Zhou X and O'Shea EK (2011) Integrated Approaches Reveal Determinants of Genome-wide Binding and Function of the Transcription Factor Pho4. Mol Cell 42(6):826-36
+'''Description of YJR060W:''' Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation<ref name='S000039955'>Cai M and Davis RW (1990) Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cell 61(3):437-46 {{SGDpaper|S000039955}} PMID 2185892</ref><ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 {{SGDpaper|S000059050}} PMID 15111622</ref><ref name='S000040724'>Kuras L, et al. (1996) A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism. EMBO J 15(10):2519-29 {{SGDpaper|S000040724}} PMID 8665859</ref><ref name='S000042200'>Mellor J, et al. (1991) DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast. Nucleic Acids Res 19(11):2961-9 {{SGDpaper|S000042200}} PMID 2057354</ref><ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 {{SGDpaper|S000059647}} PMID 11222754</ref><ref name='S000145916'>Zhou X and O'Shea EK (2011) Integrated Approaches Reveal Determinants of Genome-wide Binding and Function of the Transcription Factor Pho4. Mol Cell 42(6):826-36
   {{SGDpaper|S000145916}} PMID 21700227</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJR060W:''' Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA<ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 {{SGDpaper|S000059050}} PMID 15111622</ref><ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60
+'''Description of YJR060W:''' Helix-loop-helix trasnscription factor; binds the motif CACRTG which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA; competes with Pho4p DNA binding motif and there by helps define the specificity of Pho4p gene regulation<ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 {{SGDpaper|S000059050}} PMID 15111622</ref><ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 {{SGDpaper|S000059647}} PMID 11222754</ref><ref name='S000145916'>Zhou X and O'Shea EK (2011) Integrated Approaches Reveal Determinants of Genome-wide Binding and Function of the Transcription Factor Pho4. Mol Cell 42(6):826-36
-  {{SGDpaper|S000059647}} PMID 11222754</ref>
+  {{SGDpaper|S000145916}} PMID 21700227</ref>
 <br>
 <br>

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr X:548751..549806
+|nowrap| Chr X:548759..549814
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003821

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJR060W:''' Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA<ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 {{SGDpaper|S000059050}} PMID 15111622</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 {{SGDpaper|S000059647}} PMID 11222754</ref><ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20
+'''Description of YJR060W:''' Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA<ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23 {{SGDpaper|S000059050}} PMID 15111622</ref><ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60
-  {{SGDpaper|S000073767}} PMID 12820973</ref>
+  {{SGDpaper|S000059647}} PMID 11222754</ref>
 <br>
 <br>

@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YJR060W YJR060W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003821 YJR060W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''CBF1 ''
@@ Line 14: / Line 14: @@
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr X:548752..549807
 |}
 <br>
-'''Description of {{PAGENAME}}:''' Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA<ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 {{SGDpaper|S000059647}} PMID 11222754</ref><ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23
+'''Description of YJR060W:''' Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA<ref name='S000073767'>Moreau JL, et al. (2003) Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell 11(6):1609-20 {{SGDpaper|S000073767}} PMID 12820973</ref><ref name='S000059647'>Wieland G, et al. (2001) Determination of the binding constants of the centromere protein Cbf1 to all 16 centromere DNAs of Saccharomyces cerevisiae. Nucleic Acids Res 29(5):1054-60 {{SGDpaper|S000059647}} PMID 11222754</ref><ref name='S000059050'>Kent NA, et al. (2004) Cbf1p is required for chromatin remodeling at promoter-proximal CACGTG motifs in yeast. J Biol Chem 279(26):27116-23
   {{SGDpaper|S000059050}} PMID 15111622</ref>
 <br>
@@ Line 37: / Line 39: @@
 J Biol Chem 278(5):3265-74</ref>
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← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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 {|{{Prettytable}} align = 'right' width = '200px'
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr X:548752..549807
 |}
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 ==Community Commentary==
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