YJL156C - Revision history

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003692 YJL156C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003692 YJL156C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SSY5 ''

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr X:128948..126849
+|nowrap| Chr X:128952..126853
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003692

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJL156C:''' Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p<ref name='S000059760'>Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26 {{SGDpaper|S000059760}} PMID 11154269</ref><ref name='S000066134'>Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 {{SGDpaper|S000066134}} PMID 11679080</ref><ref name='S000114586'>Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8 {{SGDpaper|S000114586}} PMID 16524914</ref><ref name='S000120429'>Andreasson C, et al. (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8
+'''Description of YJL156C:''' Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p<ref name='S000120429'>Andreasson C, et al. (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8 {{SGDpaper|S000120429}} PMID 16778074</ref><ref name='S000059760'>Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26 {{SGDpaper|S000059760}} PMID 11154269</ref><ref name='S000066134'>Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 {{SGDpaper|S000066134}} PMID 11679080</ref><ref name='S000114586'>Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8
- {{SGDpaper|S000120429}} PMID 16778074</ref>
+ {{SGDpaper|S000114586}} PMID 16524914</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJL156C:''' Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p<ref name='S000120429'>Andreasson C, et al. (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8 {{SGDpaper|S000120429}} PMID 16778074</ref><ref name='S000114586'>Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8 {{SGDpaper|S000114586}} PMID 16524914</ref><ref name='S000066134'>Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 {{SGDpaper|S000066134}} PMID 11679080</ref><ref name='S000059760'>Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26
+'''Description of YJL156C:''' Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p<ref name='S000059760'>Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26 {{SGDpaper|S000059760}} PMID 11154269</ref><ref name='S000066134'>Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 {{SGDpaper|S000066134}} PMID 11679080</ref><ref name='S000114586'>Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8 {{SGDpaper|S000114586}} PMID 16524914</ref><ref name='S000120429'>Andreasson C, et al. (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8
-  {{SGDpaper|S000059760}} PMID 11154269</ref>
+  {{SGDpaper|S000120429}} PMID 16778074</ref>
 <br>
 <br>

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr X:128949..126886
+|nowrap| Chr X:128948..126849
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003692
 |}
 <br>
-'''Description of YJL156C:''' Probable serine protease of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that regulate expression of amino acid permease genes<ref name='S000114586'>Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8 {{SGDpaper|S000114586}} PMID 16524914</ref><ref name='S000066134'>Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 {{SGDpaper|S000066134}} PMID 11679080</ref><ref name='S000059760'>Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26
+'''Description of YJL156C:''' Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p<ref name='S000120429'>Andreasson C, et al. (2006) Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20(12):1563-8 {{SGDpaper|S000120429}} PMID 16778074</ref><ref name='S000114586'>Poulsen P, et al. (2006) Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5(3):601-8 {{SGDpaper|S000114586}} PMID 16524914</ref><ref name='S000066134'>Forsberg H, et al. (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28 {{SGDpaper|S000066134}} PMID 11679080</ref><ref name='S000059760'>Forsberg H and Ljungdahl PO (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26
   {{SGDpaper|S000059760}} PMID 11154269</ref>
 <br>
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 ==References==
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 This difference is cited in: Poulsen P, Wu B, Gaber RF, Kielland-Brandt MC. Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino acid sensor system in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Jun;4(6):1116-24. PMID: 15947203 <br> In this strain, the SSY5 ORF is 12 amino acids longer than the sequence in SGD.
-Update: Option 2 has been confirmed. The additional A is erroneous and SSY5 is indeed 699 amino acids long. SGD plans to update SSY5 sequence in December.
+Update: Option 2 has been confirmed. The additional A is erroneous and SSY5 is indeed 699 amino acids long. SGD plans to update SSY5 sequence in December, 2008.
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 The Fungal Alignment Viewer at SGD indicates that SSY5/YJL156C in S. cerevisiae contains a frame-shift in the 4th-to-last codon (addition of an A), thereby truncating the protein relative to the other sensu stricto strains. In the other strains the ORF is a dozen amino acids longer. The protein and DNA sequences are highly conserved in this region, which contains a serine protease domain.<br> There are a couple of possibilities. <br>
-) The reference genome S288C may contain this sequence and the gene is in fact shorter.<br>
+) The reference genome S288C may contain this sequence and the gene is in fact shorter (687 amino acids).<br>
 ) The reference sequence for S288C is wrong. Only sequencing of the reference strain can tell.
 <br><br>
 This difference is cited in: Poulsen P, Wu B, Gaber RF, Kielland-Brandt MC. Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino acid sensor system in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Jun;4(6):1116-24. PMID: 15947203 <br> In this strain, the SSY5 ORF is 12 amino acids longer than the sequence in SGD.
 <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->