YJL090C - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YJL090C YJL090C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''DPB11 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||'' ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr X:265046..262752
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Essential BRCT repeat protein, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control<ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17
{{SGDpaper|S000043352}} PMID 10733584</ref>
 
 
 
 

__TOC__
==Community Commentary==
{{CommentaryHelp}}

==References==

{{RefHelp}}

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr X:265045..262751
+|nowrap| Chr X:265051..262757
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003626

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJL090C:''' Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1<ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000120052'>Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 {{SGDpaper|S000120052}} PMID 17167415</ref><ref name='S000132428'>Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 {{SGDpaper|S000132428}} PMID 17167417</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000128433'>Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4
+'''Description of YJL090C:''' Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1<ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000128433'>Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4 {{SGDpaper|S000128433}} PMID 19028869</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000120052'>Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 {{SGDpaper|S000120052}} PMID 17167415</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000132428'>Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5
-  {{SGDpaper|S000128433}} PMID 19028869</ref>
+  {{SGDpaper|S000132428}} PMID 17167417</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJL090C:''' Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity<ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9
+'''Description of YJL090C:''' Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1<ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000120052'>Tanaka S, et al. (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32 {{SGDpaper|S000120052}} PMID 17167415</ref><ref name='S000132428'>Zegerman P and Diffley JF (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5 {{SGDpaper|S000132428}} PMID 17167417</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000128433'>Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4
-  {{SGDpaper|S000128012}} PMID 18922789</ref>
+  {{SGDpaper|S000128433}} PMID 19028869</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YJL090C:''' Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity<ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17
+'''Description of YJL090C:''' Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity<ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17 {{SGDpaper|S000043352}} PMID 10733584</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9
-  {{SGDpaper|S000043352}} PMID 10733584</ref>
+  {{SGDpaper|S000128012}} PMID 18922789</ref>
 <br>
 <br>

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr X:265046..262752
+|nowrap| Chr X:265045..262751
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003626
 |}
 <br>
-'''Description of YJL090C:''' Essential BRCT repeat protein, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control<ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17
+'''Description of YJL090C:''' Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases, also required for S/M checkpoint control; activates Mec1p kinase activity<ref name='S000128012'>Navadgi-Patil VM and Burgers PM (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9 {{SGDpaper|S000128012}} PMID 18922789</ref><ref name='S000073407'>Huang D and Koshland D (2003) Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Genes Dev 17(14):1741-54 {{SGDpaper|S000073407}} PMID 12865298</ref><ref name='S000069695'>Wang H and Elledge SJ (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304 {{SGDpaper|S000069695}} PMID 11973288</ref><ref name='S000056038'>Kamimura Y, et al. (1998) Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 18(10):6102-9 {{SGDpaper|S000056038}} PMID 9742127</ref><ref name='S000055675'>Ehrenhofer-Murray AE, et al. (1999) A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae. Genetics 153(3):1171-82 {{SGDpaper|S000055675}} PMID 10545450</ref><ref name='S000046281'>Wang H and Elledge SJ (1999) DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 96(7):3824-9 {{SGDpaper|S000046281}} PMID 10097122</ref><ref name='S000043352'>Masumoto H, et al. (2000) Dpb11 controls the association between DNA polymerases alpha and epsilon and the autonomously replicating sequence region of budding yeast. Mol Cell Biol 20(8):2809-17
   {{SGDpaper|S000043352}} PMID 10733584</ref>
 <br>

@@ Line 4: / Line 4: @@
 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003626 YJL090C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003626 YJL090C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''DPB11 ''

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr X:265046..262752
 |}
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 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}