YHR149C - Revision history

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← Older revision		Revision as of 16:44, 21 March 2013
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	Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper\|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>		Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper\|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>

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		+	== Transmembrane Domain GxxxG-like motif ==
		+
		+	The transmembrane domain of this protein contains GvavAvpvG. The presence of multiple, chained GxxxG-like motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Skg6p dimerises.

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001192 YHR149C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001192 YHR149C]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SKG6 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VIII:396662..394458
+|nowrap| Chr VIII:396659..394455
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000001192

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YHR149C:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 {{SGDpaper|S000061434}} PMID 11489916</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6
+'''Description of YHR149C:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 {{SGDpaper|S000061434}} PMID 11489916</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 {{SGDpaper|S000119445}} PMID 16314687</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
-  {{SGDpaper|S000119445}} PMID 16314687</ref>
+  {{SGDpaper|S000074306}} PMID 14574415</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YHR149C:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 {{SGDpaper|S000119445}} PMID 16314687</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71
+'''Description of YHR149C:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 {{SGDpaper|S000061434}} PMID 11489916</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6
-  {{SGDpaper|S000061434}} PMID 11489916</ref>
+  {{SGDpaper|S000119445}} PMID 16314687</ref>
 <br>
 <br>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''           ||'' ''
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''           || ORF, Uncharacterized[[Category:ORF]][[Category:ORF, Uncharacterized]]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''           || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
@@ Line 16: / Line 16: @@
 |}
 <br>
-'''Description of {{PAGENAME}}:''' Protein of unknown function; found in the bud tip and bud neck, potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71
+'''Description of {{PAGENAME}}:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 {{SGDpaper|S000119445}} PMID 16314687</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71
   {{SGDpaper|S000061434}} PMID 11489916</ref>
 <br>
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr VIII:396662..394458
 |}
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 ==Community Commentary==
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 ==References==
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