YGR185C - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGR185C YGR185C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''TYS1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''TTS1, TyrRS''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VII:867525..866341
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr<ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 {{SGDpaper|S000059780}} PMID 3535890</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32
{{SGDpaper|S000047982}} PMID 9294037</ref>
 
 
 
 

__TOC__
==Community Commentary==
{{CommentaryHelp}}

==References==

{{RefHelp}}

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VII:867525..866341
+|nowrap| Chr VII:867520..866336
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003417

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies<ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 {{SGDpaper|S000047982}} PMID 9294037</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 {{SGDpaper|S000059780}} PMID 3535890</ref><ref name='S000114313'>Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202
+'''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies<ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 {{SGDpaper|S000059780}} PMID 3535890</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 {{SGDpaper|S000047982}} PMID 9294037</ref><ref name='S000114313'>Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202
   {{SGDpaper|S000114313}} PMID 16429158</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr<ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 {{SGDpaper|S000047982}} PMID 9294037</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30
+'''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies<ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 {{SGDpaper|S000047982}} PMID 9294037</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 {{SGDpaper|S000059780}} PMID 3535890</ref><ref name='S000114313'>Jordanova A, et al. (2006) Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Nat Genet 38(2):197-202
-  {{SGDpaper|S000059780}} PMID 3535890</ref>
+  {{SGDpaper|S000114313}} PMID 16429158</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr<ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30 {{SGDpaper|S000059780}} PMID 3535890</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32
+'''Description of YGR185C:''' Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyr<ref name='S000047982'>Guan MX (1997) Cytoplasmic tyrosyl-tRNA synthetase rescues the defect in mitochondrial genome maintenance caused by the nuclear mutation mgm104-1 in the yeast Saccharomyces cerevisiae. Mol Gen Genet 255(5):525-32 {{SGDpaper|S000047982}} PMID 9294037</ref><ref name='S000052929'>Cavarelli J, et al. (1993) Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase. Nature 362(6416):181-4 {{SGDpaper|S000052929}} PMID 8450889</ref><ref name='S000054421'>Chow CM and RajBhandary UL (1993) Saccharomyces cerevisiae cytoplasmic tyrosyl-tRNA synthetase gene. Isolation by complementation of a mutant Escherichia coli suppressor tRNA defective in aminoacylation and sequence analysis. J Biol Chem 268(17):12855-63 {{SGDpaper|S000054421}} PMID 8509419</ref><ref name='S000059780'>Bare LA and Uhlenbeck OC (1986) Specific substitution into the anticodon loop of yeast tyrosine transfer RNA. Biochemistry 25(19):5825-30
-  {{SGDpaper|S000047982}} PMID 9294037</ref>
+  {{SGDpaper|S000059780}} PMID 3535890</ref>
 <br>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003417 YGR185C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003417 YGR185C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''TYS1 ''

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 {|{{Prettytable}} align = 'right' width = '200px'
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr VII:867525..866341
 |}
 <br>
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 <br>
 <br>
+<br>
 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}