YGR184C - Revision history

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{{PageTop}}
{|{{Prettytable}} align = 'right' width = '200px'
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YGR184C YGR184C]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''UBR1 ''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''PTR1''
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VII:865758..859906
|-
|colspan = '3'|{{Don'tEditThisBox}}
|}
 
'''Description of {{PAGENAME}}:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30():405-39 {{SGDpaper|S000058010}} PMID 8982460</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5
{{SGDpaper|S000040629}} PMID 1651502</ref>
 
 
 
 

__TOC__
==Community Commentary==
{{CommentaryHelp}}

==References==

{{RefHelp}}

@@ Line 13: / Line 13: @@
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VII:865758..859906
+|nowrap| Chr VII:865753..859901
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003416

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000044765'>Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 {{SGDpaper|S000044765}} PMID 9427760</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000132192'>Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 {{SGDpaper|S000132192}} PMID 16311597</ref><ref name='S000126742'>Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28
+'''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000044765'>Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 {{SGDpaper|S000044765}} PMID 9427760</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000126742'>Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28 {{SGDpaper|S000126742}} PMID 18566452</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000132192'>Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50
- {{SGDpaper|S000126742}} PMID 18566452</ref>
+ {{SGDpaper|S000132192}} PMID 16311597</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR184C:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39
+'''Description of YGR184C:''' E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)<ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000044765'>Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77 {{SGDpaper|S000044765}} PMID 9427760</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000132192'>Zenker M, et al. (2005) Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet 37(12):1345-50 {{SGDpaper|S000132192}} PMID 16311597</ref><ref name='S000126742'>Xia Z, et al. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. J Biol Chem 283(35):24011-28
-  {{SGDpaper|S000058010}} PMID 8982460</ref>
+  {{SGDpaper|S000126742}} PMID 18566452</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR184C:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39 {{SGDpaper|S000058010}} PMID 8982460</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5
+'''Description of YGR184C:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5 {{SGDpaper|S000040629}} PMID 1651502</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39
-  {{SGDpaper|S000040629}} PMID 1651502</ref>
+  {{SGDpaper|S000058010}} PMID 8982460</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR184C:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30():405-39 {{SGDpaper|S000058010}} PMID 8982460</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5
+'''Description of YGR184C:''' Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome<ref name='S000058010'>Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39 {{SGDpaper|S000058010}} PMID 8982460</ref><ref name='S000047686'>Xie Y and Varshavsky A (2000) Physical association of ubiquitin ligases and the 26S proteasome. Proc Natl Acad Sci U S A 97(6):2497-502 {{SGDpaper|S000047686}} PMID 10688918</ref><ref name='S000043965'>Sung P, et al. (1991) Yeast RAD6 encoded ubiquitin conjugating enzyme mediates protein degradation dependent on the N-end-recognizing E3 enzyme. EMBO J 10(8):2187-93 {{SGDpaper|S000043965}} PMID 2065660</ref><ref name='S000041112'>Bartel B, et al. (1990) The recognition component of the N-end rule pathway. EMBO J 9(10):3179-89 {{SGDpaper|S000041112}} PMID 2209542</ref><ref name='S000040629'>Dohmen RJ, et al. (1991) The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme. Proc Natl Acad Sci U S A 88(16):7351-5
   {{SGDpaper|S000040629}} PMID 1651502</ref>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003416 YGR184C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003416 YGR184C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''UBR1 ''

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>

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 {{PageTop}}
 {|{{Prettytable}} align = 'right' width = '200px'
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr VII:865758..859906
 |}
 <br>
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+<br>
 __TOC__
 ==Community Commentary==
 {{CommentaryHelp}}
 ==References==
 <!-- REFERENCES ARE AUTOMATICALLY GENERATED.  PLEASE DON'T EDIT THIS SECTION-->
 {{RefHelp}}