YGR144W - Revision history

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003376 YGR144W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003376 YGR144W]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''THI4 ''

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 |}
 <br>
-'''Description of YGR144W:''' Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents<ref name='S000120887'>Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 {{SGDpaper|S000120887}} PMID 17309261</ref><ref name='S000127167'>Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8 {{SGDpaper|S000127167}} PMID 18652458</ref><ref name='S000052703'>Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 {{SGDpaper|S000052703}} PMID 9367751</ref><ref name='S000052526'>Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90
+'''Description of YGR144W:''' Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents<ref name='S000120887'>Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 {{SGDpaper|S000120887}} PMID 17309261</ref><ref name='S000127167'>Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8 {{SGDpaper|S000127167}} PMID 18652458</ref><ref name='S000147203'>Chatterjee A, et al. (2011) Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature 478(7370):542-6 {{SGDpaper|S000147203}} PMID 22031445</ref><ref name='S000052703'>Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 {{SGDpaper|S000052703}} PMID 9367751</ref><ref name='S000052526'>Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90
   {{SGDpaper|S000052526}} PMID 7941734</ref>
 <br>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VII:780404..781384
+|nowrap| Chr VII:780399..781379
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003376

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR144W:''' Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents<ref name='S000052703'>Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 {{SGDpaper|S000052703}} PMID 9367751</ref><ref name='S000052526'>Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90 {{SGDpaper|S000052526}} PMID 7941734</ref><ref name='S000120887'>Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 {{SGDpaper|S000120887}} PMID 17309261</ref><ref name='S000127167'>Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8
+'''Description of YGR144W:''' Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents<ref name='S000120887'>Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 {{SGDpaper|S000120887}} PMID 17309261</ref><ref name='S000127167'>Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8 {{SGDpaper|S000127167}} PMID 18652458</ref><ref name='S000052703'>Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 {{SGDpaper|S000052703}} PMID 9367751</ref><ref name='S000052526'>Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90
-  {{SGDpaper|S000127167}} PMID 18652458</ref>
+  {{SGDpaper|S000052526}} PMID 7941734</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR144W:''' Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents<ref name='S000127167'>Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8 {{SGDpaper|S000127167}} PMID 18652458</ref><ref name='S000120887'>Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 {{SGDpaper|S000120887}} PMID 17309261</ref><ref name='S000052703'>Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 {{SGDpaper|S000052703}} PMID 9367751</ref><ref name='S000052526'>Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90
+'''Description of YGR144W:''' Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents<ref name='S000052703'>Machado CR, et al. (1997) Dual role for the yeast THI4 gene in thiamine biosynthesis and DNA damage tolerance. J Mol Biol 273(1):114-21 {{SGDpaper|S000052703}} PMID 9367751</ref><ref name='S000052526'>Praekelt UM, et al. (1994) Regulation of THI4 (MOL1), a thiamine-biosynthetic gene of Saccharomyces cerevisiae. Yeast 10(4):481-90 {{SGDpaper|S000052526}} PMID 7941734</ref><ref name='S000120887'>Chatterjee A, et al. (2007) Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. J Am Chem Soc 129(10):2914-22 {{SGDpaper|S000120887}} PMID 17309261</ref><ref name='S000127167'>Chatterjee A, et al. (2008) Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. J Am Chem Soc 130(34):11394-8
-  {{SGDpaper|S000052526}} PMID 7941734</ref>
+  {{SGDpaper|S000127167}} PMID 18652458</ref>
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