YGR063C - Revision history

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-'''Description of YGR063C:''' Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing<ref name='S000146227'>Anderson SJ, et al. (2011) The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively. J Biol Chem 286(21):18816-24 {{SGDpaper|S000146227}} PMID 21467039</ref><ref name='S000075983'>Crotti LB and Basrai MA (2004) Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae. EMBO J 23(8):1804-14 {{SGDpaper|S000075983}} PMID 15057281</ref><ref name='S000132618'>Ding B, et al. (2010) The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair. J Biol Chem 285(8):5317-26 {{SGDpaper|S000132618}} PMID 20042611</ref><ref name='S000146926'>Lepore N and Lafontaine DL (2011) A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast. PLoS One 6(9):e24962 {{SGDpaper|S000146926}} PMID 21949810</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 {{SGDpaper|S000120445}} PMID 16908835</ref><ref name='S000135750'>Shen Z, et al. (2010) Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud. Genes Dev 24(17):1914-26
+'''Description of YGR063C:''' Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions<ref name='S000146227'>Anderson SJ, et al. (2011) The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively. J Biol Chem 286(21):18816-24 {{SGDpaper|S000146227}} PMID 21467039</ref><ref name='S000075983'>Crotti LB and Basrai MA (2004) Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae. EMBO J 23(8):1804-14 {{SGDpaper|S000075983}} PMID 15057281</ref><ref name='S000132618'>Ding B, et al. (2010) The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair. J Biol Chem 285(8):5317-26 {{SGDpaper|S000132618}} PMID 20042611</ref><ref name='S000146926'>Lepore N and Lafontaine DL (2011) A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast. PLoS One 6(9):e24962 {{SGDpaper|S000146926}} PMID 21949810</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000148518'>Liu CR, et al. (2012) Spt4 is selectively required for transcription of extended trinucleotide repeats. Cell 148(4):690-701 {{SGDpaper|S000148518}} PMID 22341442</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 {{SGDpaper|S000120445}} PMID 16908835</ref><ref name='S000135750'>Shen Z, et al. (2010) Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud. Genes Dev 24(17):1914-26
   {{SGDpaper|S000135750}} PMID 20713510</ref>
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-'''Description of YGR063C:''' Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p<ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 {{SGDpaper|S000120445}} PMID 16908835</ref><ref name='S000059512'>Yamaguchi Y, et al. (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129(2):185-91
+'''Description of YGR063C:''' Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing<ref name='S000146227'>Anderson SJ, et al. (2011) The transcription elongation factor Spt5 influences transcription by RNA polymerase I positively and negatively. J Biol Chem 286(21):18816-24 {{SGDpaper|S000146227}} PMID 21467039</ref><ref name='S000075983'>Crotti LB and Basrai MA (2004) Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae. EMBO J 23(8):1804-14 {{SGDpaper|S000075983}} PMID 15057281</ref><ref name='S000132618'>Ding B, et al. (2010) The C-terminal repeat domain of Spt5 plays an important role in suppression of Rad26-independent transcription coupled repair. J Biol Chem 285(8):5317-26 {{SGDpaper|S000132618}} PMID 20042611</ref><ref name='S000146926'>Lepore N and Lafontaine DL (2011) A Functional Interface at the rDNA Connects rRNA Synthesis, Pre-rRNA Processing and Nucleolar Surveillance in Budding Yeast. PLoS One 6(9):e24962 {{SGDpaper|S000146926}} PMID 21949810</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 {{SGDpaper|S000120445}} PMID 16908835</ref><ref name='S000135750'>Shen Z, et al. (2010) Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud. Genes Dev 24(17):1914-26
-  {{SGDpaper|S000059512}} PMID 11173517</ref>
+  {{SGDpaper|S000135750}} PMID 20713510</ref>
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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003295 YGR063C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003295 YGR063C]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SPT4 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VII:617828..617520
+|nowrap| Chr VII:617824..617516
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003295

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR063C:''' Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p<ref name='S000059512'>Yamaguchi Y, et al. (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129(2):185-91 {{SGDpaper|S000059512}} PMID 11173517</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12
+'''Description of YGR063C:''' Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p<ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000120445'>Schneider DA, et al. (2006) RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing. Proc Natl Acad Sci U S A 103(34):12707-12 {{SGDpaper|S000120445}} PMID 16908835</ref><ref name='S000059512'>Yamaguchi Y, et al. (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129(2):185-91
-  {{SGDpaper|S000120445}} PMID 16908835</ref>
+  {{SGDpaper|S000059512}} PMID 11173517</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YGR063C:''' Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing<ref name='S000059512'>Yamaguchi Y, et al. (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129(2):185-91 {{SGDpaper|S000059512}} PMID 11173517</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000073348'>SGD (2007) Information without a citation in SGD
+'''Description of YGR063C:''' Protein that forms a complex with Spt5p and mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing; in addition, Spt4p is involved in kinetochore function and gene silencing<ref name='S000073348'>SGD (2007) Information without a citation in SGD   {{SGDpaper|S000073348}} PMID </ref><ref name='S000072823'>Rondon AG, et al. (2003) Molecular evidence for a positive role of Spt4 in transcription elongation. EMBO J 22(3):612-20 {{SGDpaper|S000072823}} PMID 12554661</ref><ref name='S000072734'>Lindstrom DL, et al. (2003) Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins. Mol Cell Biol 23(4):1368-78 {{SGDpaper|S000072734}} PMID 12556496</ref><ref name='S000059512'>Yamaguchi Y, et al. (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem 129(2):185-91
-  {{SGDpaper|S000073348}} PMID </ref>
+  {{SGDpaper|S000059512}} PMID 11173517</ref>
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