YGR023W - Revision history

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← Older revision		Revision as of 16:31, 21 March 2013
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		+	== Transmembrane Domain GxxxG ==
		+
		+	The transmembrane domain of Mtl1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiiGcvvG. The presence of a GxxxG motif <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Mtl1p dimerises.

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003255 YGR023W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003255 YGR023W]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''MTL1 ''

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 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VII:529268..530923
+|nowrap| Chr VII:529264..530919
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000003255

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 |}
 <br>
-'''Description of YGR023W:''' Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations<ref name='S000052074'>Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 {{SGDpaper|S000052074}} PMID 10348843</ref><ref name='S000048543'>Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 {{SGDpaper|S000048543}} PMID 10330137</ref><ref name='S000080345'>Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59 {{SGDpaper|S000080345}} PMID 15637049</ref><ref name='S000068904'>de Bettignies G, et al. (2001) Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics 159(4):1435-48
+'''Description of YGR023W:''' Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p<ref name='S000052074'>Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 {{SGDpaper|S000052074}} PMID 10348843</ref><ref name='S000048543'>Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 {{SGDpaper|S000048543}} PMID 10330137</ref><ref name='S000080345'>Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59
- {{SGDpaper|S000068904}} PMID 11779787</ref>
+ {{SGDpaper|S000080345}} PMID 15637049</ref>
 <br>
 <br>

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 |}
 <br>
-'''Description of YGR023W:''' Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations<ref name='S000048543'>Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 {{SGDpaper|S000048543}} PMID 10330137</ref><ref name='S000052074'>Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 {{SGDpaper|S000052074}} PMID 10348843</ref><ref name='S000080345'>Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59 {{SGDpaper|S000080345}} PMID 15637049</ref><ref name='S000068904'>de Bettignies G, et al. (2001) Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics 159(4):1435-48
+'''Description of YGR023W:''' Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations<ref name='S000052074'>Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 {{SGDpaper|S000052074}} PMID 10348843</ref><ref name='S000048543'>Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 {{SGDpaper|S000048543}} PMID 10330137</ref><ref name='S000080345'>Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59 {{SGDpaper|S000080345}} PMID 15637049</ref><ref name='S000068904'>de Bettignies G, et al. (2001) Overactivation of the protein kinase C-signaling pathway suppresses the defects of cells lacking the Rho3/Rho4-GAP Rgd1p in Saccharomyces cerevisiae. Genetics 159(4):1435-48
   {{SGDpaper|S000068904}} PMID 11779787</ref>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+
		+
		+
		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
		+	<!--
		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
		+	-->

	<protect>		<protect>