YFR027W - Revision history

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001923 YFR027W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001923 YFR027W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''ECO1 ''

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 |}
 <br>
-'''Description of YFR027W:''' Acetyltransferase required for the establishment of sister chromatid cohesion; modifies Smc3p at replication forks during S-phase and Mcd1p in response to ds DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
+'''Description of YFR027W:''' Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000134907'>Onn I, et al. (2009) The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion. Nucleic Acids Res 37(18):6126-34 {{SGDpaper|S000134907}} PMID 19692582</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
   {{SGDpaper|S000126972}} PMID 18614053</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YFR027W:''' Acetyltransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
+'''Description of YFR027W:''' Acetyltransferase required for the establishment of sister chromatid cohesion; modifies Smc3p at replication forks during S-phase and Mcd1p in response to ds DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
   {{SGDpaper|S000126972}} PMID 18614053</ref>
 <br>

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 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr VI:207440..208285
+|nowrap| Chr VI:207452..208297
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000001923

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YFR027W:''' Acetytransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
+'''Description of YFR027W:''' Acetyltransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51
   {{SGDpaper|S000126972}} PMID 18614053</ref>
 <br>