YDR159W - Revision history

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-'''Description of YDR159W:''' Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay<ref name='S000136082'>Chekanova JA, et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77 {{SGDpaper|S000136082}} PMID 18003937</ref><ref name='S000071844'>Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 {{SGDpaper|S000071844}} PMID 12411502</ref><ref name='S000073827'>Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 {{SGDpaper|S000073827}} PMID 12702719</ref><ref name='S000072894'>Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 {{SGDpaper|S000072894}} PMID 12631707</ref><ref name='S000131880'>Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 {{SGDpaper|S000131880}} PMID 19806183</ref><ref name='S000039622'>Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74 {{SGDpaper|S000039622}} PMID 2656401</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
+'''Description of YDR159W:''' Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)<ref name='S000136082'>Chekanova JA, et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77 {{SGDpaper|S000136082}} PMID 18003937</ref><ref name='S000071844'>Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 {{SGDpaper|S000071844}} PMID 12411502</ref><ref name='S000073827'>Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 {{SGDpaper|S000073827}} PMID 12702719</ref><ref name='S000072894'>Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 {{SGDpaper|S000072894}} PMID 12631707</ref><ref name='S000131880'>Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 {{SGDpaper|S000131880}} PMID 19806183</ref><ref name='S000039622'>Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74 {{SGDpaper|S000039622}} PMID 2656401</ref><ref name='S000148635'>Phimsen S, et al. (2012) Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP. Apoptosis () {{SGDpaper|S000148635}} PMID 22395445</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
   {{SGDpaper|S000146226}} PMID 21478823</ref>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002566 YDR159W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002566 YDR159W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''SAC3 ''

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YDR159W:''' Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay<ref name='S000071844'>Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 {{SGDpaper|S000071844}} PMID 12411502</ref><ref name='S000073827'>Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 {{SGDpaper|S000073827}} PMID 12702719</ref><ref name='S000072894'>Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 {{SGDpaper|S000072894}} PMID 12631707</ref><ref name='S000131880'>Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 {{SGDpaper|S000131880}} PMID 19806183</ref><ref name='S000039622'>Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74 {{SGDpaper|S000039622}} PMID 2656401</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
+'''Description of YDR159W:''' Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay<ref name='S000136082'>Chekanova JA, et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77 {{SGDpaper|S000136082}} PMID 18003937</ref><ref name='S000071844'>Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 {{SGDpaper|S000071844}} PMID 12411502</ref><ref name='S000073827'>Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 {{SGDpaper|S000073827}} PMID 12702719</ref><ref name='S000072894'>Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 {{SGDpaper|S000072894}} PMID 12631707</ref><ref name='S000131880'>Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 {{SGDpaper|S000131880}} PMID 19806183</ref><ref name='S000039622'>Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74 {{SGDpaper|S000039622}} PMID 2656401</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
   {{SGDpaper|S000146226}} PMID 21478823</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YDR159W:''' Nuclear pore-associated protein, required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus<ref name='S000071844'>Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 {{SGDpaper|S000071844}} PMID 12411502</ref><ref name='S000073827'>Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 {{SGDpaper|S000073827}} PMID 12702719</ref><ref name='S000072894'>Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 {{SGDpaper|S000072894}} PMID 12631707</ref><ref name='S000131880'>Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 {{SGDpaper|S000131880}} PMID 19806183</ref><ref name='S000039622'>Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74
+'''Description of YDR159W:''' Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay<ref name='S000071844'>Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 {{SGDpaper|S000071844}} PMID 12411502</ref><ref name='S000073827'>Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 {{SGDpaper|S000073827}} PMID 12702719</ref><ref name='S000072894'>Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 {{SGDpaper|S000072894}} PMID 12631707</ref><ref name='S000131880'>Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 {{SGDpaper|S000131880}} PMID 19806183</ref><ref name='S000039622'>Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74 {{SGDpaper|S000039622}} PMID 2656401</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
-  {{SGDpaper|S000039622}} PMID 2656401</ref>
+  {{SGDpaper|S000146226}} PMID 21478823</ref>
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@@ Line 13: / Line 13: @@
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr IV:771875..775780
+|nowrap| Chr IV:771877..775782
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000002566