YCR059C - Revision history

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-'''Description of YCR059C:''' Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene<ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 {{SGDpaper|S000054053}} PMID 10801780</ref><ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 {{SGDpaper|S000082081}} PMID 15937339</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62
+'''Description of YCR059C:''' Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT<ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 {{SGDpaper|S000054053}} PMID 10801780</ref><ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 {{SGDpaper|S000082081}} PMID 15937339</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 {{SGDpaper|S000076888}} PMID 15126500</ref><ref name='S000143536'>Sattlegger E, et al. (2011) Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2. J Biol Chem 286(12):10341-55 {{SGDpaper|S000143536}} PMID 21239490</ref><ref name='S000148776'>Waller T, et al. (2012) Evidence that Yih1 resides in a complex with ribosomes.LID - 10.1111/j.1742-4658.2012.08553.x [doi] FEBS J ()
-  {{SGDpaper|S000076888}} PMID 15126500</ref>
+  {{SGDpaper|S000148776}} PMID 22404850</ref>
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 {|{{Prettytable}} align = 'right' width = '200px'
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-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000655 YCR059C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000655 YCR059C]
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''YIH1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr III:224226..223450
+|nowrap| Chr III:224230..223454
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000000655

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 |}
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-'''Description of YCR059C:''' Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene<ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 {{SGDpaper|S000054053}} PMID 10801780</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 {{SGDpaper|S000076888}} PMID 15126500</ref><ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23
+'''Description of YCR059C:''' Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene<ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 {{SGDpaper|S000054053}} PMID 10801780</ref><ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 {{SGDpaper|S000082081}} PMID 15937339</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62
-  {{SGDpaper|S000082081}} PMID 15937339</ref>
+  {{SGDpaper|S000076888}} PMID 15126500</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YCR059C:''' Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene<ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23 {{SGDpaper|S000082081}} PMID 15937339</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 {{SGDpaper|S000076888}} PMID 15126500</ref><ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6
+'''Description of YCR059C:''' Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene<ref name='S000054053'>Kubota H, et al. (2000) GI domain-mediated association of the eukaryotic initiation factor 2alpha kinase GCN2 with its activator GCN1 is required for general amino acid control in budding yeast. J Biol Chem 275(27):20243-6 {{SGDpaper|S000054053}} PMID 10801780</ref><ref name='S000076888'>Sattlegger E, et al. (2004) YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. J Biol Chem 279(29):29952-62 {{SGDpaper|S000076888}} PMID 15126500</ref><ref name='S000082081'>Pereira CM, et al. (2005) IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. J Biol Chem 280(31):28316-23
-  {{SGDpaper|S000054053}} PMID 10801780</ref>
+  {{SGDpaper|S000082081}} PMID 15937339</ref>
 <br>
 <br>

← Older revision		Revision as of 20:02, 21 February 2007
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		+	<!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation -->
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		+	Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
		+	<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
		+	J Biol Chem 278(5):3265-74</ref>
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 |nowrap| Chr III:224226..223450
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