YBR246W - Revision history

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@@ Line 18: / Line 18: @@
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-'''Description of YBR246W:''' Diphthamide synthetase; required for last step of diphthamide biosynthesis, deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 {{SGDpaper|S000129563}} PMID 19270272</ref><ref name='S000146585'>Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () {{SGDpaper|S000146585}} PMID 21880895</ref><ref name='S000147862'>Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc ()
+'''Description of YBR246W:''' Protein required for last step of diphthamide biosynthesis; deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 {{SGDpaper|S000129563}} PMID 19270272</ref><ref name='S000146585'>Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () {{SGDpaper|S000146585}} PMID 21880895</ref><ref name='S000147862'>Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc ()
   {{SGDpaper|S000147862}} PMID 22188241</ref>
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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000450 YBR246W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000450 YBR246W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''RRT2 ''

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YBR246W:''' WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype; human ortholog is WDR85<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 {{SGDpaper|S000129563}} PMID 19270272</ref><ref name='S000146585'>Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell ()
+'''Description of YBR246W:''' Diphthamide synthetase; required for last step of diphthamide biosynthesis, deletion leads to accumulation of diphthine, which is the enzymatic product of the second step of the biosynthesis; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 {{SGDpaper|S000129563}} PMID 19270272</ref><ref name='S000146585'>Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell () {{SGDpaper|S000146585}} PMID 21880895</ref><ref name='S000147862'>Su X, et al. (2011) YBR246W Is Required for the Third Step of Diphthamide Biosynthesis. J Am Chem Soc ()
-  {{SGDpaper|S000146585}} PMID 21880895</ref>
+  {{SGDpaper|S000147862}} PMID 22188241</ref>
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 <br>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''RRT2 ''
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''           ||'' ''
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''           ||''ERE1''
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''           || ORF, Uncharacterized[[Category:ORF]][[Category:ORF, Uncharacterized]]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''           || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YBR246W:''' Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
+'''Description of YBR246W:''' WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype; human ortholog is WDR85<ref name='S000070264'>Bonangelino CJ, et al. (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501 {{SGDpaper|S000070264}} PMID 12134085</ref><ref name='S000129563'>Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19 {{SGDpaper|S000129563}} PMID 19270272</ref><ref name='S000146585'>Shi Y, et al. (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell ()
-  {{SGDpaper|S000129563}} PMID 19270272</ref>
+  {{SGDpaper|S000146585}} PMID 21880895</ref>
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 <br>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr II:711586..712749
+|nowrap| Chr II:711591..712754
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000000450

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