YBR179C - Revision history

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000383 YBR179C]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000383 YBR179C]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''FZO1 ''

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 |}
 <br>
-'''Description of YBR179C:''' Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system<ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 {{SGDpaper|S000125860}} PMID 18353967</ref><ref name='S000145143'>Cohen MM, et al. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124(Pt 9):1403-10 {{SGDpaper|S000145143}} PMID 21502136</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 {{SGDpaper|S000045931}} PMID 9786948</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5
+'''Description of YBR179C:''' Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system<ref name='S000144683'>Anton F, et al. (2011) Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci 124(Pt 7):1126-35 {{SGDpaper|S000144683}} PMID 21385840</ref><ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 {{SGDpaper|S000125860}} PMID 18353967</ref><ref name='S000145143'>Cohen MM, et al. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124(Pt 9):1403-10 {{SGDpaper|S000145143}} PMID 21502136</ref><ref name='S000116253'>Escobar-Henriques M, et al. (2006) Regulation of mitochondrial fusion by the F-box protein Mdm30 involves proteasome-independent turnover of Fzo1. J Cell Biol 173(5):645-50 {{SGDpaper|S000116253}} PMID 16735578</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 {{SGDpaper|S000045931}} PMID 9786948</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5
   {{SGDpaper|S000052886}} PMID 9685359</ref>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YBR179C:''' Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system<ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 {{SGDpaper|S000125860}} PMID 18353967</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 {{SGDpaper|S000045931}} PMID 9786948</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5
+'''Description of YBR179C:''' Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system<ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 {{SGDpaper|S000125860}} PMID 18353967</ref><ref name='S000145143'>Cohen MM, et al. (2011) Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci 124(Pt 9):1403-10 {{SGDpaper|S000145143}} PMID 21502136</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 {{SGDpaper|S000045931}} PMID 9786948</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5
   {{SGDpaper|S000052886}} PMID 9685359</ref>
 <br>

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr II:589109..586542
+|nowrap| Chr II:589114..586547
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000000383

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 |}
 <br>
-'''Description of YBR179C:''' Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system<ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 {{SGDpaper|S000045931}} PMID 9786948</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5 {{SGDpaper|S000052886}} PMID 9685359</ref><ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64
+'''Description of YBR179C:''' Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system<ref name='S000125860'>Cohen MM, et al. (2008) Ubiquitin-Proteasome-dependent Degradation of a Mitofusin, a Critical Regulator of Mitochondrial Fusion. Mol Biol Cell 19(6):2457-64 {{SGDpaper|S000125860}} PMID 18353967</ref><ref name='S000045931'>Hermann GJ, et al. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 143(2):359-73 {{SGDpaper|S000045931}} PMID 9786948</ref><ref name='S000052886'>Rapaport D, et al. (1998) Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae. J Biol Chem 273(32):20150-5
- {{SGDpaper|S000125860}} PMID 18353967</ref>
+ {{SGDpaper|S000052886}} PMID 9685359</ref>
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