YBR136W - Revision history

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-'''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres<ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000148240'>Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () {{SGDpaper|S000148240}} PMID 22289863</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65
+'''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres<ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000148240'>Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () {{SGDpaper|S000148240}} PMID 22289863</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000150401'>Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () {{SGDpaper|S000150401}} PMID 22842922</ref><ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65
   {{SGDpaper|S000054274}} PMID 7926756</ref>
 <br>

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 |}
 <br>
-'''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination<ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65
+'''Description of YBR136W:''' Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres<ref name='S000057992'>Elledge SJ (1996) Cell cycle checkpoints: preventing an identity crisis. Science 274(5293):1664-72 {{SGDpaper|S000057992}} PMID 8939848</ref><ref name='S000039357'>Grushcow JM, et al. (1999) Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice. Genetics 153(2):607-20 {{SGDpaper|S000039357}} PMID 10511543</ref><ref name='S000148240'>Hector RE, et al. (2012) Mec1p associates with functionally compromised telomeres. Chromosoma () {{SGDpaper|S000148240}} PMID 22289863</ref><ref name='S000042917'>Kato R and Ogawa H (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucleic Acids Res 22(15):3104-12 {{SGDpaper|S000042917}} PMID 8065923</ref><ref name='S000057903'>Kiser GL and Weinert TA (1996) Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol Biol Cell 7(5):703-18 {{SGDpaper|S000057903}} PMID 8744945</ref><ref name='S000058330'>Weinert T (1998) DNA damage checkpoints update: getting molecular. Curr Opin Genet Dev 8(2):185-93 {{SGDpaper|S000058330}} PMID 9610409</ref><ref name='S000054274'>Weinert TA, et al. (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8(6):652-65
   {{SGDpaper|S000054274}} PMID 7926756</ref>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000340 YBR136W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000340 YBR136W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''MEC1 ''

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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''MEC1 ''
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''           ||''ESR1, SAD3''
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''           ||''ESR1, RAD31, SAD3''
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''           || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]

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 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr II:505662..512768
+|nowrap| Chr II:505668..512774
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000000340