YAL056W - Revision history

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@@ Line 18: / Line 18: @@
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-'''Description of YAL056W:''' Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p<ref name='S000073959'>Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 {{SGDpaper|S000073959}} PMID 12538771</ref><ref name='S000070204'>Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 {{SGDpaper|S000070204}} PMID 12150916</ref><ref name='S000116741'>Harashima T, et al. (2006) The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22(6):819-30 {{SGDpaper|S000116741}} PMID 16793550</ref><ref name='S000087180'>Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 {{SGDpaper|S000087180}} PMID 16278446</ref><ref name='S000123081'>Niranjan T, et al. (2007) Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 282(33):24231-8 {{SGDpaper|S000123081}} PMID 17584745</ref><ref name='S000118053'>Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9
+'''Description of YAL056W:''' Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication<ref name='S000073959'>Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 {{SGDpaper|S000073959}} PMID 12538771</ref><ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000070204'>Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 {{SGDpaper|S000070204}} PMID 12150916</ref><ref name='S000116741'>Harashima T, et al. (2006) The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22(6):819-30 {{SGDpaper|S000116741}} PMID 16793550</ref><ref name='S000087180'>Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 {{SGDpaper|S000087180}} PMID 16278446</ref><ref name='S000123081'>Niranjan T, et al. (2007) Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 282(33):24231-8 {{SGDpaper|S000123081}} PMID 17584745</ref><ref name='S000118053'>Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9
   {{SGDpaper|S000118053}} PMID 16924114</ref>
 <br>

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 {|{{Prettytable}} align = 'right' width = '200px'
 |-
-|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000052 YAL056W]
+|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000052 YAL056W]
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''         ||''GPB2 ''

@@ Line 13: / Line 13: @@
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 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
-|nowrap| Chr I:39260..41902
+|nowrap| Chr I:39259..41901
 |-
 |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''           || S000000052

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YAL056W:''' Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p<ref name='S000087180'>Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 {{SGDpaper|S000087180}} PMID 16278446</ref><ref name='S000070204'>Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 {{SGDpaper|S000070204}} PMID 12150916</ref><ref name='S000118053'>Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9 {{SGDpaper|S000118053}} PMID 16924114</ref><ref name='S000073959'>Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 {{SGDpaper|S000073959}} PMID 12538771</ref><ref name='S000116741'>Harashima T, et al. (2006) The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22(6):819-30 {{SGDpaper|S000116741}} PMID 16793550</ref><ref name='S000123081'>Niranjan T, et al. (2007) Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 282(33):24231-8
+'''Description of YAL056W:''' Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p<ref name='S000073959'>Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 {{SGDpaper|S000073959}} PMID 12538771</ref><ref name='S000070204'>Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 {{SGDpaper|S000070204}} PMID 12150916</ref><ref name='S000116741'>Harashima T, et al. (2006) The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22(6):819-30 {{SGDpaper|S000116741}} PMID 16793550</ref><ref name='S000087180'>Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 {{SGDpaper|S000087180}} PMID 16278446</ref><ref name='S000123081'>Niranjan T, et al. (2007) Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 282(33):24231-8 {{SGDpaper|S000123081}} PMID 17584745</ref><ref name='S000118053'>Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9
-  {{SGDpaper|S000123081}} PMID 17584745</ref>
+  {{SGDpaper|S000118053}} PMID 16924114</ref>
 <br>
 <br>

@@ Line 18: / Line 18: @@
 |}
 <br>
-'''Description of YAL056W:''' Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p<ref name='S000123081'>Niranjan T, et al. (2007) Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 282(33):24231-8 {{SGDpaper|S000123081}} PMID 17584745</ref><ref name='S000118053'>Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9 {{SGDpaper|S000118053}} PMID 16924114</ref><ref name='S000116741'>Harashima T, et al. (2006) The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22(6):819-30 {{SGDpaper|S000116741}} PMID 16793550</ref><ref name='S000087180'>Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 {{SGDpaper|S000087180}} PMID 16278446</ref><ref name='S000073959'>Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 {{SGDpaper|S000073959}} PMID 12538771</ref><ref name='S000070204'>Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73
+'''Description of YAL056W:''' Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p<ref name='S000087180'>Lu A and Hirsch JP (2005) Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins. Eukaryot Cell 4(11):1794-800 {{SGDpaper|S000087180}} PMID 16278446</ref><ref name='S000070204'>Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 {{SGDpaper|S000070204}} PMID 12150916</ref><ref name='S000118053'>Peeters T, et al. (2006) Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast. Proc Natl Acad Sci U S A 103(35):13034-9 {{SGDpaper|S000118053}} PMID 16924114</ref><ref name='S000073959'>Batlle M, et al. (2003) Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J Cell Sci 116(Pt 4):701-10 {{SGDpaper|S000073959}} PMID 12538771</ref><ref name='S000116741'>Harashima T, et al. (2006) The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Mol Cell 22(6):819-30 {{SGDpaper|S000116741}} PMID 16793550</ref><ref name='S000123081'>Niranjan T, et al. (2007) Kelch repeat protein interacts with the yeast Galpha subunit Gpa2p at a site that couples receptor binding to guanine nucleotide exchange. J Biol Chem 282(33):24231-8
-  {{SGDpaper|S000070204}} PMID 12150916</ref>
+  {{SGDpaper|S000123081}} PMID 17584745</ref>
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