View source for Details of 2023 Reference Genome Annotation Update R64.4

The ''S. cerevisiae'' strain S288C reference genome annotation was updated. The new genome annotation is release R64.4.1, dated 2023-08-23. Note that the underlying genome sequence itself was not altered in any way.

==R64.4 Annotation update summary==
This annotation update included (details in table below):
*new uORFs for 3 ORFs: 
**[https://www.yeastgenome.org/locus/FPS1 FPS1/YLL043W]
**[https://www.yeastgenome.org/locus/ACC1 ACC1/YNR016C]
**[https://www.yeastgenome.org/locus/HOL1 HOL1/YNR055C]
*8 new ncRNAs: 
**[https://www.yeastgenome.org/locus/SUT035 SUT035/YNCC0015W]
**[https://www.yeastgenome.org/locus/S000345038 SUT053/YNCD0033W]
**[https://www.yeastgenome.org/locus/SUT468 SUT468/YNCD0034C]
**[https://www.yeastgenome.org/locus/SUT532 SUT532/YNCG0047C]
**[https://www.yeastgenome.org/locus/SUT125 SUT125/YNCG0048W]
**[https://www.yeastgenome.org/locus/SUT126 SUT126/YNCG0049W]
**[https://www.yeastgenome.org/locus/SUT390 SUT390/YNCP0025W]
**[https://www.yeastgenome.org/locus/SUT418 SUT418/YNCP0026W]
*3 ORFs demoted from 'Uncharacterized' to 'Dubious' based on request from NCBI because they overlap tRNAs: 
**[https://www.yeastgenome.org/locus/YDR278C YDR278C]
**[https://www.yeastgenome.org/locus/YOL013W-A YOL013W-A]
**[https://www.yeastgenome.org/locus/YPR108W-A YPR108W-A]

==R64.4 Annotation update details==
{| border="1" style="border-collapse:collapse; width:90%" cellpadding="3"
|-
! style="background: #D8D8D8" | Chr
! style="background: #D8D8D8" | Feature
! style="background: #D8D8D8" | Description of change
! style="background: #D8D8D8" | Reference
|-
|III
|[https://www.yeastgenome.org/locus/SUT035 SUT035/YNCC0015W]
|New ncRNA <br>chrIII:205766..205942 (+ strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,  
[https://www.yeastgenome.org/reference/S000300500 Balarezo-Cisneros LN, et al. (2021)] PMID:33493158
|-
|IV
|[https://www.yeastgenome.org/locus/YDR278C YDR278C]
|Change ORF qualifier from Uncharacterized to Dubious
|Requested by [https://www.ncbi.nlm.nih.gov NCBI]
|-
|IV
|[https://www.yeastgenome.org/locus/SUT053 SUT053/YNCD0033W]
|New ncRNA <br>chrIV:506334..507774 (+ strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,  
[https://www.yeastgenome.org/reference/S000300500 Balarezo-Cisneros LN, et al. (2021)] PMID:33493158
|-
|IV
|[https://www.yeastgenome.org/locus/SUT468 SUT468/YNCD0034C]
|New ncRNA <br>chrIV:506546..507450 (- strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,  
[https://www.yeastgenome.org/reference/S000300500 Balarezo-Cisneros LN, et al. (2021)] PMID:33493158
|-
|VII
|[https://www.yeastgenome.org/locus/SUT532 SUT532/YNCG0047C]
|New ncRNA <br>chrVII:17213..17709 (- strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,  
[https://www.yeastgenome.org/reference/S000300500 Balarezo-Cisneros LN, et al. (2021)] PMID:33493158
|-
|VII
|[https://www.yeastgenome.org/locus/SUT125 SUT125/YNCG0048W]
|New ncRNA <br>chrVII:650855..651159 (+ strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,
[https://www.yeastgenome.org/reference/S000300500 Balarezo-Cisneros LN, et al. (2021)] PMID:33493158, [https://www.yeastgenome.org/reference/S000341923 Feng MW, et al. (2022)] PMID:36712349 
|-
|VII
|[https://www.yeastgenome.org/locus/SUT126 SUT126/YNCG0049W]
|New ncRNA <br>chrVII:660087..661399 (+ strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,  
[https://www.yeastgenome.org/reference/S000300500 Balarezo-Cisneros LN, et al. (2021)] PMID:33493158
|-
|XII
|[https://www.yeastgenome.org/locus/FPS1 FPS1/YLL043W]
|New uORF <br>uORF2 3 codons chrXII:49924..49932 (+ strand) ATGCATTAA
|[https://www.yeastgenome.org/reference/S000205077 Cartwright SP, et al. (2017)] PMID:28279185
|-
|XIV
|[https://www.yeastgenome.org/locus/ACC1 ACC1/YNR016C]
|New uORF <br>4 codons chrXIV:661704..661715 (- strand) ATGTGTTTATAA
|[https://www.yeastgenome.org/reference/S000204657 Blank HM, et al. (2017)] PMID:28057705
|-
|XIV
|[https://www.yeastgenome.org/locus/HOL1 HOL1/YNR055C]
|New uORF <br>7 codons chrXIV:730381..730401 (- strand) ATGCTATTACTACCAAGTTGA
|[https://www.yeastgenome.org/reference/S000306549 Vindu A, et al. (2021)] PMID:34375581
|-
|XV
|[https://www.yeastgenome.org/locus/YOL013W-A YOL013W-A]
|Change ORF qualifier from Uncharacterized to Dubious
|Requested by [https://www.ncbi.nlm.nih.gov NCBI]
|-
|XVI
|[https://www.yeastgenome.org/locus/SUT390 SUT390/YNCP0025W]
|New ncRNA <br>chrXVI:52977..53465 (+ strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243,  [https://www.yeastgenome.org/reference/S000341923 Feng MW, et al. (2022)] PMID:36712349
|-
|XVI
|[https://www.yeastgenome.org/locus/SUT418 SUT418/YNCP0026W]
|New ncRNA <br>chrXVI:588998..589830 (+ strand)
|[https://www.yeastgenome.org/reference/S000129105 Xu Z, et al. (2009)] PMID:19169243, [https://www.yeastgenome.org/reference/S000341923 Feng MW, et al. (2022)] PMID:36712349
|-
|XVI
|[https://www.yeastgenome.org/locus/YPR108W-A YPR108W-A]
|Change ORF qualifier from Uncharacterized to Dubious
|Requested by [https://www.ncbi.nlm.nih.gov NCBI]
|-
|}