YHR081W

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Systematic name YHR081W
Gene name LRP1
Aliases RRP47, YC1D
Feature type ORF, Verified
Coordinates Chr VIII:267538..268092
Primary SGDID S000001123


Description of YHR081W: Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination[1][2][3][4]




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References

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  1. Hieronymus H, et al. (2004) Genome-wide mRNA surveillance is coupled to mRNA export. Genes Dev 18(21):2652-62 SGD PMID 15489286
  2. Mitchell P, et al. (2003) Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs. Mol Cell Biol 23(19):6982-92 SGD PMID 12972615
  3. Stead JA, et al. (2007) The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein. Nucleic Acids Res 35(16):5556-67 SGD PMID 17704127
  4. Vodala S, et al. (2008) The nuclear exosome and adenylation regulate posttranscriptional tethering of yeast GAL genes to the nuclear periphery. Mol Cell 31(1):104-13 SGD PMID 18614049

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