YGR233C

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Systematic name YGR233C
Gene name PHO81
Aliases VAC6, phoS
Feature type ORF, Verified
Coordinates Chr VII:958210..954674
Primary SGDID S000003465


Description of YGR233C: Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p[1][2][3][4]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in phosphorus limited chemostat cultures versus phosphorus excess. [5] [6]





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References

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  1. Creasy CL, et al. (1996) Negative transcriptional regulation of PH081 expression in Saccharomyces cerevisiae. Gene 168(1):23-9 SGD PMID 8626060
  2. Huang S, et al. (2001) Functional analysis of the cyclin-dependent kinase inhibitor Pho81 identifies a novel inhibitory domain. Mol Cell Biol 21(19):6695-705 SGD PMID 11533256
  3. Lee M, et al. (2000) Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81. Mol Microbiol 38(2):411-22 SGD PMID 11069666
  4. Lee YS, et al. (2007) Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. Science 316(5821):109-12 SGD PMID 17412959
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

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