YEL021W

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Systematic name YEL021W
Gene name URA3
Aliases
Feature type ORF, Verified
Coordinates Chr V:116167..116970
Primary SGDID S000000747


Description of YEL021W: Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound[1][2][3][4][5][6]




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References

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  1. Alani E and Kleckner N (1987) A new type of fusion analysis applicable to many organisms: protein fusions to the URA3 gene of yeast. Genetics 117(1):5-12 SGD PMID 3311876
  2. Boeke JD, et al. (1984) A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol Gen Genet 197(2):345-6 SGD PMID 6394957
  3. Boeke JD, et al. (1987) 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol 154:164-75 SGD PMID 3323810
  4. Jones ME (1992) Orotidylate decarboxylase of yeast and man. Curr Top Cell Regul 33:331-42 SGD PMID 1499340
  5. Lacroute F (1968) Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae. J Bacteriol 95(3):824-32 SGD PMID 5651325
  6. Umezu K, et al. (1971) Purification and properties of orotidine-5'-phosphate pyrophosphorylase and orotidine-5'-phosphate decarboxylase from baker's yeast. J Biochem 70(2):249-62 SGD PMID 5094209

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