YDR062W
(Redirected from TSC1)
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| Systematic name | YDR062W |
| Gene name | LCB2 |
| Aliases | SCS1, TSC1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:576474..578159 |
| Primary SGDID | S000002469 |
Description of YDR062W: Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine[1][2]
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References
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- ↑ Nagiec MM, et al. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A 91(17):7899-902 SGD PMID 8058731
- ↑ Zhao C, et al. (1994) Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. J Biol Chem 269(34):21480-8 SGD PMID 8063782
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