YDR310C
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| Systematic name | YDR310C |
| Gene name | SUM1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1084316..1081128 |
| Primary SGDID | S000002718 |
Description of YDR310C: Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint[1][2][3][4][5][6]
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Interactions
Physical
Physical interaction with Hst1
Sum1, a repressor of middle meiotic genes, was found to interact with Hst1 by coimmunoprecipitation. A neomorphic allele of Sum1 (Sum1-1) also interacts with Hst1. Hst1 is a histone deacetylase, and it is required for repression of some Sum1 targets. [7] [8]
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References
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- ↑ Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
- ↑ Irlbacher H, et al. (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22 SGD PMID 16077008
- ↑ Klar AJ, et al. (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58 SGD PMID 3905506
- ↑ Laurenson P and Rine J (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96 SGD PMID 1752414
- ↑ Lindgren A, et al. (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97 SGD PMID 11101521
- ↑ Xie J, et al. (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54 SGD PMID 10562556
- ↑ Rusche LN and Rine J (2001) Conversion of a gene-specific repressor to a regional silencer. Genes Dev 15(8):955-67 SGD PMID 11316790
- ↑ submitted by Hunter Fraser on 2003-03-14
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