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Systematic name YNL283C
Gene name WSC2
Aliases STA3
Feature type ORF, Verified
Coordinates Chr XIV:106695..105184
Primary SGDID S000005227

Description of YNL283C: Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response[1][2][3][4][5][6][7]


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Transmembrane Domain GxxxG

The transmembrane domain of Wsc2p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with GlsgGaiaGvvvGvvcG. The presence of multiple, overlapping GxxxG motifs [8] strongly indicates that wsc2 multimerises.



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  1. Imazu H and Sakurai H (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6 SGD PMID 15947197
  2. Kosodo Y, et al. (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14 SGD PMID 11481671
  3. Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9 SGD PMID 11545731
  4. Ng DT (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20 SGD PMID 11702943
  5. Raboy B, et al. (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39 SGD PMID 10361277
  6. Verna J, et al. (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9 SGD PMID 9391108
  7. Zu T, et al. (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55 SGD PMID 11589572
  8. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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