YJL076W
(Redirected from SRM8)
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| Systematic name | YJL076W |
| Gene name | NET1 |
| Aliases | CFI1, ESC5, SRM8 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:295245..298814 |
| Primary SGDID | S000003612 |
Description of YJL076W: Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Shou W, et al. (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97(2):233-44 SGD PMID 10219244
- ↑ Shou W, et al. (2001) Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol Cell 8(1):45-55 SGD PMID 11511359
- ↑ Straight AF, et al. (1999) Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97(2):245-56 SGD PMID 10219245
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-27
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