YER022W
(Redirected from SRB4)
Share your knowledge...Edit this entry! <protect>
| Systematic name | YER022W |
| Gene name | SRB4 |
| Aliases | MED17 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:198812..200875 |
| Primary SGDID | S000000824 |
Description of YER022W: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination[1][2][3]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
<protect>
References
See Help:References on how to add references
- ↑ Kaufmann R, et al. (2010) Infantile Cerebral and Cerebellar Atrophy Is Associated with a Mutation in the MED17 Subunit of the Transcription Preinitiation Mediator Complex. Am J Hum Genet 87(5):667-70 SGD PMID 20950787
- ↑ Kornberg RD (2005) Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 30(5):235-9 SGD PMID 15896740
- ↑ Thompson CM, et al. (1993) A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. Cell 73(7):1361-75 SGD PMID 8324825
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
