YML055W

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Systematic name YML055W
Gene name SPC2
Aliases SPY1
Feature type ORF, Verified
Coordinates Chr XIII:164790..165326
Primary SGDID S000004519


Description of YML055W: Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25[1][2][3][4]




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References

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  1. Antonin W, et al. (2000) Interactions between Spc2p and other components of the endoplasmic reticulum translocation sites of the yeast Saccharomyces cerevisiae. J Biol Chem 275(44):34068-72 SGD PMID 10921929
  2. Fang H, et al. (1997) In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. J Biol Chem 272(20):13152-8 SGD PMID 9148930
  3. Meyer HA and Hartmann E (1997) The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity. J Biol Chem 272(20):13159-64 SGD PMID 9148931
  4. Mullins C, et al. (1996) Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. J Biol Chem 271(46):29094-9 SGD PMID 8910564

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