YDR224C
(Redirected from SPT12)
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| Systematic name | YDR224C |
| Gene name | HTB1 |
| Aliases | SPT12 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:914712..914317 |
| Primary SGDID | S000002632 |
Description of YDR224C: Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation[1][2][3][4][5][6][7]
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References
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- ↑ Briggs SD, et al. (2002) Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418(6897):498 SGD PMID 12152067
- ↑ Dover J, et al. (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71 SGD PMID 12070136
- ↑ Hwang WW, et al. (2003) A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell 11(1):261-6 SGD PMID 12535538
- ↑ Kao CF, et al. (2004) Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B. Genes Dev 18(2):184-95 SGD PMID 14752010
- ↑ Martini EM, et al. (2002) A role for histone H2B during repair of UV-induced DNA damage in Saccharomyces cerevisiae. Genetics 160(4):1375-87 SGD PMID 11973294
- ↑ Robzyk K, et al. (2000) Rad6-dependent ubiquitination of histone H2B in yeast. Science 287(5452):501-4 SGD PMID 10642555
- ↑ Yamashita K, et al. (2004) Rad6-Bre1-mediated histone H2B ubiquitylation modulates the formation of double-strand breaks during meiosis. Proc Natl Acad Sci U S A 101(31):11380-5 SGD PMID 15280549
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