YKR072C
(Redirected from SIS2)
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| Systematic name | YKR072C |
| Gene name | SIS2 |
| Aliases | HAL3 |
| Feature type | ORF, Verified |
| Coordinates | Chr XI:578123..576435 |
| Primary SGDID | S000001780 |
Description of YKR072C: Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis[1][2][3]
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References
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- ↑ Ruiz A, et al. (2009) Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol 5(12):920-8 SGD PMID 19915539
- ↑ Yenush L, et al. (2002) The Ppz protein phosphatases are key regulators of K+ and pH homeostasis: implications for salt tolerance, cell wall integrity and cell cycle progression. EMBO J 21(5):920-9 SGD PMID 11867520
- ↑ de Nadal E, et al. (1998) The yeast halotolerance determinant Hal3p is an inhibitory subunit of the Ppz1p Ser/Thr protein phosphatase. Proc Natl Acad Sci U S A 95(13):7357-62 SGD PMID 9636153
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