YKR101W

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Systematic name YKR101W
Gene name SIR1
Aliases
Feature type ORF, Verified
Coordinates Chr XI:640540..642504
Primary SGDID S000001809


Description of YKR101W: Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin[1][2][3]




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References

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  1. Bose ME, et al. (2004) The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Mol Cell Biol 24(2):774-86 SGD PMID 14701749
  2. Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22 SGD PMID 3297920
  3. Sharp JA, et al. (2003) The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. Genes Dev 17(19):2356-61 SGD PMID 12975325

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