YOR057W

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Systematic name YOR057W
Gene name SGT1
Aliases YOR29-08
Feature type ORF, Verified
Coordinates Chr XV:432186..433373
Primary SGDID S000005583


Description of YOR057W: Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes[1][2][3]




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References

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  1. Catlett MG and Kaplan KB (2006) Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p. J Biol Chem 281(44):33739-48 SGD PMID 16945921
  2. Dubacq C, et al. (2002) Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryot Cell 1(4):568-82 SGD PMID 12456005
  3. Kitagawa K, et al. (1999) SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell 4(1):21-33 SGD PMID 10445024

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