YPL094C
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| Systematic name | YPL094C |
| Gene name | SEC62 |
| Aliases | LPG14 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:370663..369839 |
| Primary SGDID | S000006015 |
Description of YPL094C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]
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Contents
Community Commentary
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DNA and RNA Details
Transcription Start
Transcription start(s): 369837,370712 Transcription starts at co-ordinate 370694 or 370695 [2] [4]
Interactions
Two Hybrid
Two Hybrid interaction with SEC63
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]
Protein Details
Mature Length (direct evidence)
Protein length: 274 aa The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. [2] [4]
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References
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- ↑ Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 SGD PMID 2687286
- ↑ 2.0 2.1 2.2 2.3 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
- ↑ Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
- ↑ 4.0 4.1 4.2 submitted by Colin Stirling on 2003-02-05
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