YPL094C

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Systematic name YPL094C
Gene name SEC62
Aliases LPG14
Feature type ORF, Verified
Coordinates Chr XVI:370663..369839
Primary SGDID S000006015


Description of YPL094C: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER[1][2][3]




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Community Commentary

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DNA and RNA Details

Transcription Start

Transcription start(s): 369837,370712 Transcription starts at co-ordinate 370694 or 370695 [2] [4]


Interactions

Two Hybrid

Two Hybrid interaction with SEC63
Amino terminal domain of Sec62p (residues 1-149) interacts with c-terminal 39 residues of Sec63p [2] [4]


Protein Details

Mature Length (direct evidence)

Protein length: 274 aa The authentic translation start occurs at the AUG codon located at co-ordinate 370658 and not at the cryptic AUG located 27bp upstream (370685). The primary translation product is thus 274 amino acid residues in length and not 283 as previously supposed. [2] [4]





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References

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  1. Deshaies RJ and Schekman R (1989) SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. J Cell Biol 109(6 Pt 1):2653-64 SGD PMID 2687286
  2. 2.0 2.1 2.2 2.3 Willer M, et al. (2003) Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Yeast 20(2):133-48 SGD PMID 12518317
  3. Young BP, et al. (2001) Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. EMBO J 20(1-2):262-71 SGD PMID 11226176
  4. 4.0 4.1 4.2 submitted by Colin Stirling on 2003-02-05

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