YDL139C

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Systematic name YDL139C
Gene name SCM3
Aliases
Feature type ORF, Verified
Coordinates Chr IV:212046..211375
Primary SGDID S000002298


Description of YDL139C: Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation[1][2][3][4]




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References

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  1. Aravind L, et al. (2007) Domain architectures of the Scm3p protein provide insights into centromere function and evolution. Cell Cycle 6(20):2511-5 SGD PMID 17704645
  2. Chen Y, et al. (2000) The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol Cell Biol 20(18):7037-48 SGD PMID 10958698
  3. Hewawasam G, et al. (2010) Psh1 Is an E3 Ubiquitin Ligase that Targets the Centromeric Histone Variant Cse4. Mol Cell 40(3):444-54 SGD PMID 21070970
  4. Stoler S, et al. (2007) Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Proc Natl Acad Sci U S A 104(25):10571-6 SGD PMID 17548816

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