YPR119W

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Systematic name YPR119W
Gene name CLB2
Aliases
Feature type ORF, Verified
Coordinates Chr XVI:771653..773128
Primary SGDID S000006323


Description of YPR119W: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome[1][2][3][4]




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DNA and RNA Details

RNA Degradation

mRNA is degraded by RNase MRP [5] [6]





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References

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  1. Fitch I, et al. (1992) Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol Biol Cell 3(7):805-18 SGD PMID 1387566
  2. Ghiara JB, et al. (1991) A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell 65(1):163-74 SGD PMID 1849458
  3. Mendenhall MD and Hodge AE (1998) Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol Mol Biol Rev 62(4):1191-243 SGD PMID 9841670
  4. Surana U, et al. (1991) The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65(1):145-61 SGD PMID 1849457
  5. Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 SGD PMID 14729943
  6. submitted by Mark Schmitt on 2004-04-07

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