YOR211C
Share your knowledge...Edit this entry! <protect>
| Systematic name | YOR211C |
| Gene name | MGM1 |
| Aliases | MNA1 |
| Feature type | ORF, Verified |
| Coordinates | Chr XV:741569..738924 |
| Primary SGDID | S000005737 |
Description of YOR211C: Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy[1][2][3][4][5][6]
</protect>
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Protein Details
Mature Length (direct evidence)
Protein length: 822 aa The N-terminus of the mature large isoform of Mgm1p starts at position 81 (ISHFPKII...; 822 aa). The N-terminus of the mature short isoform of Mgm1p starts at position 161 (ATLIAATS...; 742 aa) are alternatively at position 163 (LIAATS...; 740 aa). [7] [8]
Protein Function/Process
Both isoforms of Mgm1p are required for maintenance of mitochondrial morphology and of mitochondrial DNA. [7] [8]
Protein Localization
Large and short isoform are localized to the mitochondrial intermembrane space. The large isoform is anchored via a single N-terminal transmembrane segment to the mitochondrial inner membrane which is absent in the short isoform. [7] [8]
<protect>
References
See Help:References on how to add references
- ↑ Amutha B, et al. (2004) A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Biochem J 381(Pt 1):19-23 SGD PMID 15125685
- ↑ Olichon A, et al. (2002) The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space. FEBS Lett 523(1-3):171-6 SGD PMID 12123827
- ↑ Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460
- ↑ Sesaki H, et al. (2003) Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane. Mol Biol Cell 14(6):2342-56 SGD PMID 12808034
- ↑ Wong ED, et al. (2000) The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. J Cell Biol 151(2):341-52 SGD PMID 11038181
- ↑ Zick M, et al. (2009) Distinct roles of the two isoforms of the dynamin-like GTPase Mgm1 in mitochondrial fusion. FEBS Lett 583(13):2237-43 SGD PMID 19505460
- ↑ 7.0 7.1 7.2 Herlan M, et al. (2003) Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. J Biol Chem 278(30):27781-8 SGD PMID 12707284
- ↑ 8.0 8.1 8.2 submitted by Andreas Reichert on 2003-09-25
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
