YOL126C

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Systematic name YOL126C
Gene name MDH2
Aliases
Feature type ORF, Verified
Coordinates Chr XV:82920..81787
Primary SGDID S000005486


Description of YOL126C: Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1[1][2][3]




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Community Commentary

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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in sulfur limited chemostat cultures versus sulfur excess. [4] [5]


Other Topic: expression

Specifically higher expression in carbon limited chemostat cultures versus carbon excess. [4] [5]





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References

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  1. Gibson N and McAlister-Henn L (2003) Physical and genetic interactions of cytosolic malate dehydrogenase with other gluconeogenic enzymes. J Biol Chem 278(28):25628-36 SGD PMID 12730240
  2. Lorenz MC and Fink GR (2001) The glyoxylate cycle is required for fungal virulence. Nature 412(6842):83-6 SGD PMID 11452311
  3. Minard KI and McAlister-Henn L (1991) Isolation, nucleotide sequence analysis, and disruption of the MDH2 gene from Saccharomyces cerevisiae: evidence for three isozymes of yeast malate dehydrogenase. Mol Cell Biol 11(1):370-80 SGD PMID 1986231
  4. 4.0 4.1 Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  5. 5.0 5.1 submitted by Viktor Boer on 2003-07-25

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