YNL135C

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Systematic name YNL135C
Gene name FPR1
Aliases FKB1, RBP1
Feature type ORF, Verified
Coordinates Chr XIV:372226..371882
Primary SGDID S000005079


Description of YNL135C: Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function[1][2][3]




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References

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  1. Dolinski KJ and Heitman J (1999) Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics 151(3):935-44 SGD PMID 10049913
  2. Heitman J, et al. (1991) FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(5):1948-52 SGD PMID 1705713
  3. Koltin Y, et al. (1991) Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol Cell Biol 11(3):1718-23 SGD PMID 1996117

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